穴位埋线联合免疫调节剂治疗银屑病的临床观察  

Clinical observation of catgut-embedding and oral transfer factor capsules combined for the treatment of psoriasis

作　　者：任虹[1] 匡薇薇[1] 张瑞丽[1] 解春桃[1] 邵银红[1] 

机构地区：[1]连云港市第一人民医院皮肤科,江苏连云港222002

出　　处：《江苏大学学报（医学版）》2010年第4期332-334,338,共4页Journal of Jiangsu University：Medicine Edition

摘　　要：目的:观察穴位埋线联合免疫调节剂(转移因子胶囊)治疗银屑病的临床疗效,探讨其可能作用机制。方法:将160例进行期寻常型银屑病患者随机分为两组:治疗组80例,采用穴位埋线联合免疫调节剂治疗;对照组80例,采用单纯免疫调节剂治疗。检测各组患者治疗前后血清肿瘤坏死因子-α(TNF-α)和白介素-8(IL-8)水平。结果:治疗组有效率为81.25%,对照组有效率为57.50%,两组疗效差异有统计学意义(P<0.01)。两组治愈病例复发率比较,差异有统计学意义(P<0.05)。TNF-α、IL-8水平较治疗前明显下降(P<0.01),且治疗组较对照组下降更明显(P<0.01)。结论:穴位埋线联合免疫调节剂治疗银屑病疗效好,能有效降低银屑病的复发率,显著降低血清TNF-α、IL-8水平可能是其作用机制之一。Objective： To observe the therapeutic effect and mechanism of catgut-embedding and oral taken transfer factor capsules combined therapy on psoriasis. Methods： One hundred and sixty cases of patients with acute psoriasis vulgaris were chosen and divided into treatment group （80 cases） and control group（80 cases） randomly. Treatment group was treated by the method of catgut-embedding at acupuncture point and oral taken transfer factor capsules. Control group was only treated with oral taken transfer factor capsules. The serum levels of TNF-α and IL-8 were also detected before and after the treatment. Results： The total effective rates of treatment group and control group were 81.25% and 57.50% respectively. Compared with each other, the difference was significant（P 〈0.01 ）. In all curative cases,the relapse rate of treatment group was lower than that of control group （ P 〈 0.05 ）. After the treatment the serum levels of TNF-α and IL-8 in treatment group and control group were lower than that before the treatment respectively （P 〈 0. 01 ）. And there was significant difference between treatment group and control group after treatment （P 〈 0. 01 ）. Conclusion： The observation showed that applying catgut-embedding and oral transfer factor capsules combined therapy on psoriasis was much more effective than only treated with oral transfer factor capsules. It can decrease the relapse rate of curative cases significantly, and cut down the serum levels of TNF-α and IL-8 obviously, which may be one of the mechanism.

关 键 词：穴位埋线 免疫调节剂 进行期寻常型银屑病 肿瘤坏死因子-α 白介素-8 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]