辛伐他汀对2型糖尿病患者尿白蛋白的影响  

Effect of Simvastatin on Albuminuria in Type 2 Diabetes Mellitus Patients

作　　者：李春燕[1] 刘清平[1] 李金[1] 

机构地区：[1]长沙医学院附属湘潭市二医院内分泌科,湖南湘潭411100

出　　处：《医学临床研究》2010年第7期1229-1231,共3页Journal of Clinical Research

摘　　要：【目的】应用辛伐他汀治疗2型糖尿病（T2DM）早期肾病，观察患者尿白蛋白，c反应蛋白（C—RP）的变化。【方法】T2DM早期肾病患者[尿蛋白排泄率（UAER）20～200μg／min]60例，随机分为辛伐他汀治疗组和非辛伐他汀治疗组，各30例，测定血糖，血脂，UAER，CRP等。另选30名健康者和30例单纯T2DM患者作对照。【结果】辛伐他汀治疗组和非辛伐他汀治疗组治疗后，血糖，TC，UAER，CRP均较治疗前下降，治疗后两组间比较差异有显著性（P〈0．01）。HDL－C治疗后逐渐升高，与非辛伐他汀组比较差异有显著性（P〈0．05）。【结论】辛伐他汀可有效降低血脂，C—RP的同时，降低uAER水平，使用辛伐他汀进行干预可有效减轻糖尿病肾病患者尿白蛋白。[Objective]To study the effect of simvastatin on albuminuria and C-reactive protein（C RP） in type 2 diabetes mellitus（T2DM） patients. [Methods] Sixty early diabetic nephropathy（DN） patients were randomly divided into simvastatin treatment group（SI group） and non-simvatatin treatment group（non-SI group） with 30 cases in each. In addition, 30 healthy people and 30 single T2DM patients were selected for the control. Blood glucose, blood lipid, UAER and C RP were measured. [Results]Compared with before treatment, blood glucose, TC, UAER and C-RP in SI and non SI group after treatment were decreased, and there was significant difference between two groups（ P 〈0.01）. After treatment, the level of HDLC was increased gradually, and there was significant difference between two groups（ P 〈0.05）. [Conclusion] Simvastatin can effectively decrease blood lipids, C- RP and UAER. The intervention with simvastatin can efficiently alleviate albuminuria in DN patients.

关 键 词：糖尿病 非胰岛素依赖型/药物疗法 斯伐他汀/药理学 白蛋白尿 

分 类 号：R587.1[医药卫生—内分泌]