不同检测方法诊断CINⅢ级的价值及宫颈锥切治疗的有效性分析  

Clinical Analysis of 51 Cases of Cervical Intraepithelial Neoplasia Ⅲ

作　　者：王晓兰[1] 李建军[1] 周燕飞[1] 

机构地区：[1]长沙市妇幼保健院,湖南长沙410008

出　　处：《医学临床研究》2010年第7期1249-1251,共3页Journal of Clinical Research

摘　　要：【目的】探讨宫颈液基薄层细胞检测（TCT）、高危型人乳头瘤病毒（HPV）检测、阴道镜下宫颈多点活检与宫颈冷刀锥切（CKC）对宫颈上度内瘤样变Ⅲ（CINⅢ）级的诊断及治疗价值。【方法】对2004年1月至2009年1月本院51例经阴道镜下多点活检诊断为CINⅢ的患者进行回顾性分析，应用SPSS16．0软件包进行处理。比较宫颈冷刀锥切和子宫全切组之间病理结果与术前活检结果符合率有无差异；比较不同年龄组的TCT结果及HPV感染情况。【结果】宫颈锥切组和子宫切除组之间手术病理与术前阴道镜活检符合率无差异性；大部分CINⅢ患者TCT异常、HPV感染，且与不同年龄相关。【结论】TCT、HPV检测联合阴道镜下多点活检是CINUI诊断的重要手段，宫颈冷刀锥切是治疗CINⅢ的一种重要方法。[Objective] To explore the value of liquid-based cytology test（TCT）, high-risk HPV test, multi-point biopsy under colposcope and cervical cold-knife conization （CKC） in the diagnosis and treatment of cervical intraepithelial neoplasia Ⅲ （CIN Ⅲ）. [Methods] A total of 51 CIN Ⅲ patients diagnosed by multipoint biopsy under colposcopy between January 2004 and January 2009 in the hospital were analyzed retrospectively. Software SPSS16.0 was used for clinical data. The pathological findings with the preoperative biopsy results between cervical cold knife conization group and total hysterectomy group were compared. TCT results and HPV infections among different age groups were also compared. [Results]There was no significant difference in pathological findings with the preoperative biopsy results between cervical cold knife conization group and total hysterectomy group. Most patients with CIN Ⅲ had abnormal TCT results and apparent HPV infec tions, which were correlated with the age. [Conclusion]TCT, HPV test combined with multi-point biopsy un der colposcope is an important method of diagnosing CIN Ⅲ, and cervical cold knife conization is an important method for treating CIN Ⅲ.

关 键 词：宫颈上皮内瘤样病变 

分 类 号：R711.74[医药卫生—妇产科学]