氯诺昔康对胆道手术患者血清IL-2和IL-10的影响  

Effect of Lornoxicam on Serum IL-2 and IL-10 Concentration in Patients with Operation on Biliary Tract

作　　者：杨彤飚 

机构地区：[1]湖南省永州市人民医院,湖南永州425000

出　　处：《医学临床研究》2010年第7期1266-1267,1270,共3页Journal of Clinical Research

摘　　要：【目的】观察氯诺昔康对胆道手术病人血清白细胞介素-2（IL-2）和血清白细胞介素-10（IL-IO）的影响。【方法】选择确诊肝外胆管结石行开腹胆道手术患者60例，随机分为氯诺昔康组和对照组（n=30），氯诺昔康组在麻醉前静脉滴注氯诺昔康8mg／20mL；对照组于麻醉前注入同等容量的生理盐水。于注药前、手术结束即刻、术后6h和术后24h抽取外周静脉血，测定血清IL-2和IL-10浓度。【结果】两组患者注药前血清IL-2和IL-10浓度变化无显著差异，手术结束即刻和术后6h、24h，对照组IL-2水平显著高于氯诺昔康组（P〈0．05），IL-10水平显著低于氯诺昔康组（P〈O．05）。【结论】氯诺昔康在胆道手术中能有效地抑制术后炎性因子血清IL-2产生并促进抗炎因子IL-10产生。[Objective]To observe the effect of lornoxicam on serum interleukin-2（IL-2） and interleukinq0（IL-10） in patients with operation on biliary tract. [Methods] Sixty cases of extrahepatic biliary stone undergoing operation on biliary tract were selected and randomly divided into lornoxicam group（group L, n = 30） and control group （group C, n = 30）. Patients in group L were given 8mg/20ml lornoxicam through intravenous infusion before anesthesia. Patients in group C were given 20ml normal saline before anesthesia. Peripheral venous blood was collected before drug injection and at Oh, 6h and 24h after operation for determining serum IL-2 and IL-10 concentra- tionl [Results] Serum IL-2 and IL-10 concentration of patients in two groups had no significant difference before drug injection（ P 〉0.05）. The level of IL-2 in group C at Oh, 6h and 24h after operation was significantly higher than that in group L（ P 〈0.05）, while the level of IL-10 in group C was significantly lower than that in group L （ P 〈0.05）. [Conclusion] Lornoxicam used in operation on biliary tract can effectively inhibit the production of serum inflammatory factor IL-2, and promote the production of anti-inflammatory factor IL-10.

关 键 词：胆道外科手术 消炎药 非甾类/药理学 白细胞介素2/血液 白细胞介素10/血液 

分 类 号：R657.4[医药卫生—外科学]