甘氨酸对高脂饮食诱导小鼠高脂血症的保护作用  

Protective effect of glycine on hyperlipidemia induced steatosis of liver in mice

作　　者：刘靖[1] 陆大祥[2] 王华东[2] 戚仁斌[2] 

机构地区：[1]佛山市佛山科学技术学院医学院生理教研室,广东省528031 [2]广东省暨南大学医学院

出　　处：《实用肝脏病杂志》2010年第4期256-257,262,共3页Journal of Practical Hepatology

基　　金：广州市科技计划项目(2004Z3-E4081);佛山科学技术学院校级科研项目

摘　　要：目的研究甘氨酸(Gly)降低高脂血症小鼠血脂的作用。方法将40只小鼠随机分为对照组、高脂组、小剂量和大剂量甘氨酸处理组,在不同处理2周后,取血测定小鼠血酯水平、肝组织丙二醛(MDA)和超氧化物歧化酶(SOD)活性,及观察肝组织病理形态学表现。结果与对照组比,高脂饮食小鼠TC、LDL、HDL-C、MDA含量明显增高(P<0.05),SOD活性下降(P<0.05);与高脂血症动物比,甘氨酸处理小鼠血TC、LDL明显降低(P<0.01),MDA含量下降(P<0.05),SOD活性升高(P<0.05);高脂血症小鼠肝组织可见弥漫性脂肪变性,而甘氨酸处理动物肝细胞内脂滴小且少。结论甘氨酸可通过调节血脂代谢增强抗氧化能力,从而能防治高脂血症所致的肝脂肪变性。Objective To study effects of glycine on reducing blood lipids and protecting liver in mice with hyperlipidemia. Methods 40 mice were randomly divided into control,high and low fat diet and glycinetreated groups. Total cholesterol （TC）,triglyceride （TG）,high density lipoprotein cholesterol （HDL-C）,low density lipoprotein（LDL）levels and arteriosclerosis index（AI）were measured after 2 weeks. The activity of superoxide dismutase（SOD）and liver malondialdehyde（MDA）content in livers were also measured. Results TC,LDL,HDL-C,AI and MDA content in high fat diet group increased significantly as compared with in control（P〈0.01）;as compared with high fat diet group,the activity of SOD in liver increased（P〈0.05）,MDA in liver decreased（P〈0.05）and plasma TC and LDL decreased（P〈0.01） in glycine-treated groups;the hepatic steatosis improved obviously also in livers of glycine-treated mice. Conclusion Glycine can regulate lipid metabolism and enhance the antioxidation to prevent hyperlipidemia and hepatic steatosis.

关 键 词：高脂血症 肝脂肪变性 甘氨酸 小鼠 

分 类 号：R589.2[医药卫生—内分泌]