粪肠球菌聚集物质的研究进展  

Development of the study on E. faecalis Aggregation substance

作　　者：羽晓瑜[1] 陆玉霞[1] 

机构地区：[1]苏州卫生职业技术学院检验药学系,江苏苏州215009

出　　处：《中国微生态学杂志》2010年第7期666-668,共3页Chinese Journal of Microecology

摘　　要：肠球菌是近年来医院感染的重要病原菌之一,粪肠球菌和部分屎肠球菌分泌产生的聚集物质(AS)是肠球菌重要的毒力因子。聚集物质是性信息素反应质粒在性信息素反应中表达的表面连接蛋白,介导细菌间质粒的接合转移、细菌聚集黏附及细菌与真核细胞的黏附,在肠球菌毒力和抗生素耐药传递中发挥着重要作用。本文就聚集物质的致病性、生成与调控作一综述。Enterococcus is the most common pathogen isolated from nosocomial infections.Aggregation substance（AS）,a pheromone-inducible surface protein of E.faecalis encoded by pheromone-responsive plasmids and expressed in response to pheromone induction,plays an important role in virulence and antibiotic resistance transfer.Aggregation substance mediates conjugation of plasmids,aggregation and binding of eukaryocytes with other germ cells.

关 键 词：粪肠球菌 集物质 进展 

分 类 号：R378.992[医药卫生—病原生物学]