急性心肌梗死患者血同型半胱氨酸水平及干预效果的研究  

Study of the plasma homocysteine level of the patients with acute myocardial infarction and intervention effect

作　　者：赵翠萍[1] 姜丽丝[1] 王召军[1] 潘文静[1] 于晓顿[1] 张静[1] 付艳东[1] 梁兆光[1] 

机构地区：[1]哈尔滨医科大学附属第一临床医学院心内科,150001

出　　处：《中国急救医学》2010年第7期633-634,共2页Chinese Journal of Critical Care Medicine

基　　金：基金项目：国家自然科学基金国际合作项目（No.30410103169）;黑龙江省教委资助项目（No.11521157）

摘　　要：目的 研究急性心肌梗死（AMI）患者血同型半胱氨酸（Hcy）水平及叶酸、维生素B12的干预效果.方法 将104例AMI患者随机分为两组,治疗1组只给常规治疗,治疗2组在常规治疗基础上给予叶酸和维生素B12口服;取正常人40例为对照组.治疗前和治疗14 d后测定血Hcy水平.结果治疗前AMI患者Hcy水平明显高于对照组（P〈0.05）;治疗14 d后治疗2组血Hcy水平明显降低（P〈0.05）,与治疗1组和治疗前比较差异有统计学意义（P＜0.05）.结论 AMI患者Hcy水平明显升高,叶酸和维生素B12能明显降低AMI患者Hcy水平.Objective To study the plasma homocysteine （Hey） level of the patients with acute myocardial infarction（AMI） and to observe the effects of folic acid and Vitamin B12 on the Hey level of the patients. Methods 104 patients diagnosed as coronary heart disease （AMI） were randomly divided into two groups： the AMI group and the treatment group. The AMI group received routine medical therapy, while the treatment group received oral Vitamin B12 and folic acid besides routine medical therapy. 40 cases of normal persons were as control group. Before the treatment and 14 days after the treatment, plasma Hey levels in every group were observed. Results The Hey in AMI patients was higher than that in control group before the treatment（ P 〈 0. 05 ）. 14 days after medical therapy, Hey level of the treatment group was lower compared with the AMI group or before treatment （ P 〈 0.05 ）. Conclusion Hey level of AMI patients was higher than that of normal person, Vitamin B12 and folic acid can decrease plasma Hey level in the AMI patients obviously.

关 键 词：急性心肌梗死 同型半胱氨酸 叶酸 维生素B12 

分 类 号：R54[医药卫生—心血管疾病]