脓毒症时树突状细胞的病理改变及临床意义  

Pathological changes of dendritic cells in sepsis and clinical significance

作　　者：章德文(综述)[1] 何建(审校)[1] 

机构地区：[1]解放军第二军医大学附属长海医院急诊科,上海200433

出　　处：《中国急救医学》2010年第7期644-646,共3页Chinese Journal of Critical Care Medicine

摘　　要：目前,脓毒症仍然是重症监护室的主要死亡原因,其特征性的免疫功能紊乱尤其是晚期特异性免疫抑制越来越被重视.树突状细胞（DC）是体内功能最强的抗原呈递细胞,能够刺激、诱导初始型T细胞增殖、分化,因此被认为是特异性免疫反应的启动者.脓毒症时,DC数量的下降、表达MHCⅡ及其刺激分子能力下降,从而影响T淋巴细胞的活化、分化,直接导致Th1细胞减少,削弱机体的细胞免疫.而通过补充DC或促进其增殖、分化,可以明显改善脓毒症时的免疫抑制状态,提高生存率.因此,针对DC的干预策略可能成为治疗脓毒症的新思路.Currently severe sepsis is a major cause of death in intensive care unit, characterized by disorders of immune function, especially the late - specific immune suppression, which have been taken seriously more and more. Dendritic cells （DCs） are the most powerful antigen - presenting cells in vivo, stimulating naive T cell proliferation and differentiation, which is regarded as the initiator - specific immune response. In sepsis the number of DCs decline, the expression of MHC Ⅱ and costimulatory molecules reduce, which affect T lymphocyte activation and differentiation, result in the decrease of Thl cells, and weaken the body＇s cell - mediated immunity. Additional DCs or promoting their proliferation and differentiation can significantly improve the immunosuppressive status of sepsis and improve survival rate. Therefore, intervention strategies for DCs may be a new idea for treatment of sepsis.

关 键 词：脓毒症 树突状细胞(DC) 凋亡 病理改变 

分 类 号：R392.12[医药卫生—免疫学]