当归补血汤主要活性成分与其理化参数的关系研究  

Researches on relationships between main active ingredients and physical and chemical parameters of Dangguibuxue decoction

作　　者：马家骅[1] 李霞[2] 张明令[3] 李楠[2] 郑琴[3] 杨明[2,3] 

机构地区：[1]西南科技大学,四川绵阳621010 [2]成都中医药大学,四川成都611137 [3]江西中医学院现代中药制剂教育部重点实验室,江西南昌330004

出　　处：《中国中药杂志》2010年第15期1953-1956,共4页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目(30801550)

摘　　要：目的:研究当归补血汤主要活性成分与其理化参数的关系,探索利用理化参数来表征中药汤剂质量的可行性。方法:以当归补血汤中的主要活性成分阿魏酸和黄芪甲苷为溶质,分别配成不同成分种类、浓度和比例的水溶液,测定其在25℃时的表面张力、pH和电导率等理化参数,并进行多项式回归分析。结果:随着阿魏酸浓度增大,阿魏酸水溶液的pH降低、电导率增大;随着黄芪甲苷浓度增大,黄芪甲苷水溶液的表面张力降低;在阿魏酸与黄芪甲苷配伍的溶液中,影响pH和电导率的主导成分是阿魏酸,影响表面张力的主导成分是黄芪甲苷。结论:黄芪甲苷与当归补血汤主要活性成分体系的表面张力相关性显著,与pH和电导率基本不相关,而阿魏酸与pH和电导率相关性显著,与表面张力基本不相关,且各自的抗干扰力强,基本不会随着另外一种物质的加入而发生变化,初步表明可以用上述特征参数来表征体系的质量。Objective：To study relationships between the main active ingredients and physical and chemical parameters of Dangguibuxue decoction,and to explore the feasibility of characterization the quality of decoction by physical and chemical parameters.Method：Solutions of ferulic acid and astragaloside with different concentrations were prepared,of which physical and chemical parameters such as surface tension,pH value and conductivity,etc were determined at 25 ℃.And polynomial regression analysis was used to analyze these data.Result：With the increase of concentration of ferulic acid,pH value was decreased and conductivity was increased.And surface tension was decreased in the aqueous solution of astragaloside.In the combined solution of ferulic acid and astragaloside,ferulic acid was the main influencing pH value and conductivity,while astragaloside was the main factor influencing surface tension.Conclusion：On one hand,astragaloside concentration has a significant correlation with surface tension,but almost no correlation with pH value and conductivity.On the other hand,ferulic acid concentration has a strong correlation with pH value and conductivity,but almost no correlation with surface tension.In addition,each parameter has strong anti-interference ability and almost didn＇t change with the addition of another material.These preliminary results suggested that such characteristic parameters could be used to characterize the decoction quality.

关 键 词：当归补血汤 主要活性成分 理化参数 质量控制 

分 类 号：R284.1[医药卫生—中药学]