3种促透剂对钩藤体外透皮吸收的影响  

Effects of Three Different Penetration Enchancers on Transdermal Absorption of the Extract of Ramulus Uncariae Cum Uncis in Vitro

作　　者：王晓颖[1] 叶梦屏[1] 

机构地区：[1]福建中医药大学药物制剂教研室,福州350108

出　　处：《中国现代应用药学》2010年第7期623-625,共3页Chinese Journal of Modern Applied Pharmacy

基　　金：福建省教育厅项目(JA07122);福建省自然科学基金项目(2008J0291)

摘　　要：目的研究氮酮、冰片、薄荷脑3种促透剂对钩藤体外透皮吸收的影响。方法用改良Franz扩散池,选择大鼠背皮为渗透屏障,从接受室取样,用HPLC测定样品中钩藤碱含量,比较3种促透剂对钩藤透皮吸收的影响。结果不同浓度的3种促透剂对钩藤碱的透皮效果皆以5%为最佳,含5%氮酮、5%冰片、5%薄荷脑的钩藤提取液平均透皮速率分别为1.00,0.92,0.87μg·cm-2·h-1,使钩藤碱透皮速率分别提高2.44,2.24,1.95倍。结论 3种促透剂皆可以促进钩藤主要活性成分钩藤碱的透皮吸收,在实验浓度范围内,以5%氮酮促渗透效果最好。OBJECTIVE To study the effects of three different penetration enchancers on the transdermal absorption of the extract of Ramulus Uncariae cum uncis in vitro. METHODS Using the extracorporeal back skin of rat as the penetration barrier in a improved Franz diffusion cell, the percutaneous rates of rhynchophylline at various concentrations of azone, bornel and methol were compared by determining the content of rhynchophylline by HPLC. RESULTS The average percutaneous rate of rhynchophylline were 1.00, 0.92, 0.87 μg·cm-2·h-1 respectively corresponding to the concentrations of azone, bornel and menthol at 5%, the enhancing rate （ER） were 2.44, 2.24, 1.95, respectively. CONCLUSION Azone, bornel and menthol can enhance transdermal absorption of rhynchophylline （the main active ingredient in Ramulus Uncariae cum uncis）, and in study range of concentrations of azone, bornel and methol, the effect of promoting penetration of 5% azone is the best.

关 键 词：钩藤碱 氮酮 冰片 薄荷脑 经皮给药 透皮吸收 

分 类 号：R943.43[医药卫生—药剂学]