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作 者:穆德广[1] 金发光[1] 楚东岭[1] 孙瑞琳[1]
机构地区:[1]第四军医大学唐都医院呼吸内科,西安市710038
出 处:《实用医学杂志》2010年第15期2717-2719,共3页The Journal of Practical Medicine
摘 要:目的:探讨丹参多酚酸盐对急性肺损伤/急性呼吸窘迫综合征(ALI/ARDS)的防治作用。方法:大耳白兔24只,随机分为正常对照组、内毒素组、丹参多酚酸盐干预组,每组8只。内毒素组于0及12h由气管内滴入内毒素(1mL/kg),复制ALI/ARDS动物模型;正常对照组气管内滴入等量生理盐水;丹参多酚酸盐干预组第一次滴入内毒素后6、12、18h静推丹参多酚酸盐(50mg/kg)。其后分别测定各组TNF-α、IL-1、动脉血氧分压、外周血白细胞计数、肺系数(肺湿重/体重)、肺湿/干比,并取肺活组织行HE染色。结果:丹参多酚酸盐干预组氧分压、肺系数和肺湿/干比、外周血白细胞、TNF-α、IL-1与对照组及内毒素组比较差异均有显著性(P<0.05)。病理学显示,丹参多酚酸盐干预组肺损伤程度减轻。结论:丹参多酚酸盐对ALI/ARDS有防治作用。Objective To observe the preventive effect of Salvianolate injection against acute lung injury/ acute respiratory distress syndrome (ALI/ARDS). Methods 24 rabbits were randomly divided into three groups: control group(n = 8), injury group (n = 8), treatment group (n = 8). The injury group were given endotoxin (1 mL/kg) by intratraeheal instillation twice at an interval of 12 hours ; the control group were given normal saline ( 1 mL/kg) ,and the treatment group were given Salvianolate (50 mg/kg) 6, 12, 18 h after the first instillation of endotoxin (1 mL/kg).The concentration of TNF-α, IL-1 in the serum, PaO2,the count of peripheral blood leukocytes, lung index (wet weigh/body weight), lung's wet/dry weigh ratio (W/D) were measured. Results There were differences between PaO2, lung index, W/D ratio, the count of peripheral blood leukocytes, TNF-α, and IL-1 concentration of Salvianolate treatment group and other two groups (P 〈 0.05). Pathology showed Salvianolate treatment group modified lung injury. Conclusion Salvianolate has preventive effect against acute lung injury.
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