荧光免疫偏振法测定丙戊酸钠血药浓度的质控评价  

Evaluation of Plasma Concentration Monitoring Method for Sodium Valproate by Fluorescence Polarization Immunoassay

作　　者：孔晶[1] 龚磊[1] 黄怡[1] 

机构地区：[1]遵义医学院附属医院药剂科,遵义市563003

出　　处：《中国药房》2010年第30期2844-2846,共3页China Pharmacy

摘　　要：目的:探讨丙戊酸钠(VPA)血药浓度监测的质量控制,确保其监测质量。方法:采用荧光免疫偏振(FPIA)法,对我院2008年VPA随行质控样本测定值进行统计学分析和连续性评价。结果:所监测低、中、高质控样本的平均回收率及相对标准差(RSD)分别为98.37%、99.33%、98.17%和1.94%、2.88%、4.10%。所测定质控样本的RSD<5%,符合《中国药典》对生物样品测定RSD的规定。结论:FPIA法在长期的VPA血药浓度监测中能提供准确、稳定的监测结果。OBJECTIVE：To explore quality control of plasma concentration monitoring for sodium valproate and to improve the quality of pharmaceutical monitoring.METHODS：The statistical and continuous analysis of sodium valproate control data from our hospital of 2008 were conducted using fluorescence polarization immunoassay（FPIA）.RESULTS：Mean recovery and RSD were 98.37% and 1.94% for low control samples,99.33% and 2.88% for medium control samples,98.17% and 4.10% for high control samples.The RSD of sample was lower than 5% and in line with the requirement for biological sample determination in Chinese Pharmacopoeia.CONCLUSION：FPIA is a comparatively accurate and stable method for plasma concentration monitoring of sodium valproate.

关 键 词：荧光偏振免疫法 质量控制 丙戊酸钠 

分 类 号：R969.3[医药卫生—药理学]