不可分型流感嗜血杆菌蛋白D研究进展  

Advances in the research of protein D of nontypeable Haemophilus influenzae

作　　者：陈祥鹏(综述)[1] 王健(综述)[1] 张振龙(审校)[1] 

机构地区：[1]北京生物制品研究所中试一室,100024

出　　处：《国际生物制品学杂志》2010年第4期205-208,共4页International Journal of Biologicals

摘　　要：流感嗜血杆菌（Haemophilus influenzae,Hi）蛋白D（Protein D,PD）是高度保守的表面脂蛋白,相对分子质量42 000,存在于所有的可分型Hi和不可分型Hi（nontypeable Haemophilus influenzae,NTHi）中,是一种具有甘油磷酸二酯酶活性的细菌毒力因子,能导致宿主上皮细胞释放磷酸胆碱,在Hi引起呼吸道感染过程中起重要作用.以NTHi PD作为载体蛋白的肺炎链球菌多糖结合疫苗,不但能预防肺炎链球菌性耳炎,而且对NTHi引起的急性中耳炎也具有预防作用.PD是迄今为止第一种能在人类机体中诱导保护性应答的NTHi抗原,也是最具潜力的多糖结合疫苗候选载体蛋白.Protein D （PD） is a highly conserved surface lipoprotein（M, 42 000） found in all Hae mophilus influenzae （Hi）, including nontypeable Haemophilus influenzae （NTHi）.PD is a virulence factor with glycerophosphodiesterase activity, which can lead to the release of phosphorylcholine from host epithelial cells, and plays an important role in the pathogenesis of respiratory tract infection caused by Hi.Pneumococcal polysaccharide conjugate vaccine using NTHi PD as a carrier protein can protect against acute otitis media caused by both pneumococci and NTHi.PD is not only a potential carrier protein candidate for polysaccharide conjugate vaccines but also the first NTHi antigen which can induce protective response in human.

关 键 词：嗜血菌 流感 载体蛋白质类 抗原 蛋白D 

分 类 号：R378.4[医药卫生—病原生物学]