气道平滑肌异常在支气管哮喘病理生理中的作用  

Role of airway smooth muscle abnormalities in bronchial asthma

作　　者：胥武剑[1] 李强[1] 

机构地区：[1]第二军医大学附属长海医院呼吸内科,上海200433

出　　处：《国际呼吸杂志》2010年第15期926-929,共4页International Journal of Respiration

摘　　要：支气管哮喘（简称哮喘）的发病过程中,气道平滑肌细胞在哮喘相关的炎症介质的作用下,出现肥大、增殖活性增强、凋亡减少、迁移、表型转变及动力学异常等改变.此种气道平滑肌的异常最终导致了气道阻力增加和气道高反应性.因此,深入了解导致气道平滑肌异常的表现及机制,寻找更加合理有效的治疗靶点,将是未来哮喘治疗的新方向.Airway smooth muscle cells underwent hyperplasia, hypertrophy, hypoapoptosis and abnormal migration, phenotype switch and mechanical contraction in the process of asthma. Such abnormalities eventually resulted in high airway resistance and airway hyperreactivity. It is important to figure out the mechanisms underlining these abnormalities and to identify more reasonable and effective target for future therapeutic usage.

关 键 词：哮喘 气道重塑 气道平滑肌 

分 类 号：R562.25[医药卫生—呼吸系统]