冻干辐照人脐动脉的制备及其物理性能的实验研究  

AN EXPERIMENTAL STUDY OF LYOPILIZE IRRADIATED UMDILICAL ARTERY ALLOGRAFT MECHANICAL BEHAVIOR

作　　者：钱涛[1,2,3,4] 翁品光 余正[1,2,3,4] 钱晶[1,2,3,4] 戴鸿贵 

机构地区：[1]南京大学医学院临床学院鼓楼医院 [2]南京大学物理系 [3]江苏省中医院预防保健科 [4]江苏省农科院原子能所

出　　处：《南京大学学报（自然科学版）》1999年第2期169-173,共5页Journal of Nanjing University（Natural Science）

摘　　要：为寻找理想的冠状血管移植物——同种异体小口径血管移植材料，１９９３年７月至１９９４年５月，自行制备采用冻干辐照方法处理人脐动脉血管并进行物理性能的比较．结果表明，经冻干辐照处理之后，该脐动脉血管的物理性能改善，弹性和顺应性都明显提高，仍然保持良好的耐压能力，能够满足移植血管物理性能方面的要求。To search for an ideal ideal allograft as coronary artery bypass graft, from July,1993 to May, 1994,we selected lyophilization radiation as a method to modify human umbilical artery allograft. We had a comparative study to test mechanical behavior in three groups(Group Ⅰ. fresh allograft; groupⅡ. freeze dried allograft; Group Ⅲ, lyophilize irradiated allograft.) The testing range of pressure was 0 40 kPa. Compared with that of group groupⅠ, the elasticity of group Ⅱand Ⅲhad improved within the testing range. Group Ⅱ had Ⅲkept better pliability at higher pressure: at 10 kPa, the pliability(1/kPa) of group Ⅰ、Ⅱ、Ⅲ was (11.82±4.20)×10 3 ,(9.03±2.42)×10 3 ,(7.00±1.94)×10 3 ,respectively(Ⅲ vs Ⅰ:NS; Ⅲ vs Ⅰ: P >0.01); at 25 kPa, they were (4.68±3.63)×10 3 ,(9.24±2.63)×10 3 ,(6.66±1.13)×10 3 ,respectively (Ⅲ vsⅠ: P >0.001;ⅢvsⅠ; P >0.05).We think this change of allograft pliability is benificial to coronary bypass graft. We consider after further research, this lyophilize irradiated allograft has broad and glorious prospect of clinical application in the area of small caliber artery (especially in coronary artery bypass) transplantation.

关 键 词：血管移植 冻干辐照 人脐动脉 物理性能 

分 类 号：R654.3[医药卫生—外科学]