CD4^+CD25^+调节性T细胞与人类获得性免疫缺陷病毒感染关系的研究进展  

The role of regulatory T lymphocyte in human immunodeficiency syndrome

作　　者：贺琼[1] 徐赫[1] 杜桂书[1] 邓路瑶[1] 吴利洋[1] 徐兰[1] 王月丹[1] 

机构地区：[1]北京大学基础医学院免疫学系,北京大学医学部生物医学实验教学中心,北京100083

出　　处：《中国科技论文在线》2007年第11期819-822,共4页

基　　金：教育部新世纪优秀人才培养计划;国家自然科学基金委员会理科基地基金;北京大学医学部创新人才培养计划

摘　　要：CD4^+CD25^+调节性T细胞,是调节性T细胞中功能最重要的一类。它是一类具有特殊免疫调节功能的T细胞亚群。它能够抑制自身免疫病的发生和发展,参与肿瘤免疫的调节,同时在感染和移植免疫中也发挥着极其重要的作用。T细胞的这一亚群具有免疫调节和免疫抑制的特性,新近发现它亦与艾滋病的发生、发展关系密切。HIV进入人体后,CD4^+CD25^+调节性T细胞抑制了机体的免疫效应但它也同时被感染,最终由于细胞毒的作用而死亡。由于调节性T细胞数量的减少不能有效地发挥其抑制作用,HIV持续的过度活化使得T细胞逐渐耗竭说明在HIV发生、发展的不同阶段Treg细胞可能都发挥了免疫抑制作用,但是却对HIV感染与艾滋病发病的进程产生了不同的效应。此外,CD4^+CD25^+调节性T细胞还与HIV病毒的持续存在密切相关。本文就CD4^+CD25^+调节性T细胞与人类获得性免疫缺陷病毒(HIV)感染之间关系进行初步的探讨。CD4＋CD25＋regulatory T cell is one of most important subsets of regulatory T cells which serves the special function of regulation. These cells can prevent autoimmune diseases, regulate the antitumor immunity and play a crucial role in suppressing immune responses to both inflammation and transplantation. This subset is hyporesponsive and anergic to antigen stimulation. Most recently, it was demonstrated that they participated in the immune deficiency in human immunodeficiency virus （HIV） infection and have close relationship with the development of aquired immunodeficiency syndrome （AIDS）. Besides the CD4 cells the CD4＋CD25＋ Treg is also infected when the HIV invades the human body. The CD4＋CD25＋ Treg was finally be killed by the mechanism of antibody-dependent cell-mediated cytotoxicity （ADCC）. As a result of the decrease of the CD4＋CD25＋ Treg, it can＇t function as an immune suppressor. There is nothing to prevent the over activation of the T cells and the T cell was killed because of the activation induced cell death （AICD）.The CD4＋CD25＋ Treg plays a different role in the development of the HIV although it functions as the immune suppressor all the time. The CD4＋CD25＋ Treg is also associated with the persist survival of the HIV. Here we review the knowledge and some new discoveries of the role CD4＋CD25＋ Treg plays in HIV infection.

关 键 词：HIV 艾滋病 调节性T细胞 感染 

分 类 号：R392.9[医药卫生—免疫学]