复方甘草酸苷治疗慢性重型病毒性肝炎的疗效和血清细胞因子变化  

Clinical studies on treatment of chronic severe viral hepatitis with SNMC and changes of serum cytokines

作　　者：黄燕[1] 贺常东 谢建萍[1] 范学工[1] 

机构地区：[1]中南大学湘雅医院感染病科,湖南长沙410008 [2]湖南省郴州市嘉禾县人民医院

出　　处：《中华实验和临床感染病杂志（电子版）》2007年第2期83-85,共3页Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition)

基　　金：湖南省卫生厅科研基金项目(00022)

摘　　要：目的研究复方甘草酸苷治疗慢性重型肝炎的临床疗效。方法86例慢性重型乙型肝炎患者,随机分为2组,对照组采用综合治疗,治疗组在综合治疗基础上加用复方甘草酸苷80～100ml/d加入10%的葡萄糖溶液中静脉滴注,疗程4周。观察2组症状、体征的变化,检测所有患者在治疗前后肝功能、凝血酶原活动度(PTA)和腹水的深度,血清K+和Na+,以及治疗前后血清肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6),白细胞介素-8(IL-8)的变化。结果治疗结束时2组的症状体征均有不同程度的改善,治疗组的好转率要显著高于对照组(81%,65%,P<0.05)。治疗组的总胆红素(TBil)要显著低于对照组(P<0.01),而PTA显著高于对照组(P<0.05)。IL-6和IL-8治疗组较对照组下降明显(P<0.01),而TNF-α2组治疗后无显著差异。血清K+和Na+的水平2组治疗前后均无明显差异。治疗组未见明显的腹水增加。结论复方甘草酸苷可使慢性重型肝炎患者的病情在4周内得到明显的改善,显著降低血清中TNF-α、IL-6和IL-8的含量。Objective To investigate the therapeutic effect of stronger neo-minophagen C （SNMC） on chronic severe viral hepatitis. Methods Eighty-six patients with chronic severe hepatits B were enrolled randomizely into treatment group （43 cases） and control group （43 cases）. The treatment group received comprehensive therapy and SNMC 80-100 mg daily,while the control group only received comprehensive treatment. The plasma levels of tumor necrosis factor-α （TNF-α）,interleukin-6 （IL-6）,interleukin-8 （IL-8） and other clinical features were observed before and after treatment. Results The clinical syndromes and signs were improved in two groups after treatment. The improvement rate of treatment group was higher than that of control group （81% vs 65%,P0.05）. After 4 weeks treatment,the serum levels of TBil,IL-6 and IL-8 decreased and PTA increased significantly in treatment group than that in control group （P0.05）. No difference was found for serum TNF-α,K＋and Na＋ in two groups. The ascites did not increase in treatment group. Conclusions SNMC can effectively improve the patient＇s condition of patients with chronic severe viral hepatitis in 4 weeks and decreased the serum levels of TNF-α,IL-6 and IL-8.

关 键 词：肝炎 肿瘤坏死因子-Α 

分 类 号：R512.6[医药卫生—内科学]