诱导性多能干细胞形成过程中转录因子的研究进展  

Research Progress of Transcription Factor in the Formation of Induced Pluripotent Stem Cells

作　　者：唐海燕[1] 沈晓丽[1] 

机构地区：[1]福建医科大学省立临床医学院,福建省心血管病重点实验室,福州350001

出　　处：《医学综述》2010年第15期2250-2253,共4页Medical Recapitulate

基　　金：福建省条件建设项目(2005Q006);福建省科技厅社会发展重点项目(2009Y0009)

摘　　要：诱导性多能干细胞(iPS)是以反转录病毒为载体将胚胎特异性转录因子导入体细胞,使其诱导分化为具有胚胎干细胞(ESCs)特性的细胞。这种多能干细胞在细胞形态、增殖速率、致瘤性、基因表达以及形成嵌合小鼠的能力上与ESCs有许多相似之处,将来可能成为ESCs在临床应用中的替代。现对iPS细胞相关的几种转录因子及其在重编程过程中的作用,以及转导基因的选择予以综述。Induced pluripotent stem cells（iPS）were retrovirus vector,to import the embryo-specific transcription factor into body cells,to induce differentiation to cells with characteristics of the embryonic stem cells（ESCs）.This pluripotent stem cells in cell morphology,proliferation rate,tumorigenicity,gene expression and the capacity of the formation of chimeric mice have many similarities with ESCs,and may be used as a substitute for the clinical application of ESC.the crucial roles of transcription factors in nuclear reprogramming and transduction genes′selection.This article briefly summarized the iPS cells about several transcription factors,its role in the process of re-programming,and genetic selection for transduction.

关 键 词：诱导性多能干细胞 转录因子 重编程 

分 类 号：R318.5[医药卫生—生物医学工程]