HO-1抗氧化损伤的研究进展  

Study on Heme Oxygenase Protection Against Oxidative Injury

作　　者：朱子夫[1] 马莉[1] 

机构地区：[1]昆明医学院第一附属医院麻醉科,昆明650032

出　　处：《医学综述》2010年第15期2266-2270,共5页Medical Recapitulate

摘　　要：血红素氧合酶1(HO-1)催化血红素降解生成胆红素,一氧化碳和Fe2+,这个表面平淡无奇的催化反应却引起人们越来越多的注意。HO-1的活性直接影响到抗氧化损伤的能力的变化。现已证实HO-1具有抗炎、抗凋亡、抗增殖的作用。同时还发现,在许多疾病(如败血症和动脉粥样硬化)中起着保护作用。但是,HO-1产生保护作用的机制现在仍然没有完全明确,本综述重点介绍HO-1的功能。Heme oxygenase-1（HO-1）functions to catabolize heme into bilirubin,carbon monoxide,and free iron.Remarkably,however,such common activity of this enzyme results in profound changes in cellular abilities to protect themselves against oxidative injuries.HO-1 has been shown to have anti-inflammatory,antiapoptotic,and antiproliferative effects,and it is now known to have beneficial effects in diseases such as atherosclerosis and sepsis.The mechanism through which HO-1 confers its protective effects is still poorly understood.This review highlights the current study on the function of HO-1.

关 键 词：血红素氧合酶1 氧化损伤 细胞凋亡 

分 类 号：Q55[生物学—生物化学]