干扰素治疗对慢性乙型病毒性肝炎患者T淋巴细胞亚群的影响  

Characteristics of T-lymphocyte Subsets in Chronic Hepatitis B Patients Receiving Interferon-α Therapy

作　　者：王昕红[1] 王天宝[1] 禹萌[1] 张光文[1] 

机构地区：[1]新乡医学院第一附属医院感染疾病科,河南卫辉453100

出　　处：《医学综述》2010年第15期2382-2383,共2页Medical Recapitulate

摘　　要：目的观察干扰素α治疗对慢性乙型病毒性肝炎患者T淋巴细胞亚群的影响。方法 56例慢性乙型病毒性肝炎患者分为干扰素治疗组(36例)和对照组(20例),疗程24周,观察两组治疗后的ALT、AST、HBV DNA水平及T细胞亚群的变化。结果治疗组治疗后,ALT、AST、HBV DNA水平均明显下降,外周血CD4+、CD8+T细胞计数及CD4+/CD8+升高,与治疗前比较及与对照组治疗后比较,差异均有统计学意义(P<0.05)。结论干扰素α可使慢性乙型病毒性肝炎患者的CD4+T细胞、CD8+T细胞数目增多,且CD4+/CD8+升高,有效抑制慢性乙型肝炎患者HBV DNA复制,明显改善肝功能。Objective To identify the impacts of interferon-α on the number of T-lymphocyte subsets in chronic hepatitis B patients.Methods Chronic hepatitis B patients（n-56）were divided into interferon-α group（n= 36）and control group（n= 20）.The course of treatment was six months.The levels of serum alanine transaminase（ALT）,HBV DNA and T-lymphocyte subsets were evaluated.Results In interferon-α group,the levels of ALT and HBV DNA were significantly lower than those in control group（P0.05; P0.01）.The number of CD4＋ and CD8＋ T-lymphocyte subsets in peripheral blood as well as CD4＋/CD8＋ ratio were significantly higher than those in control group（P0.05; P0.01）.Conclusion The results suggested that interferon-α can inhibit the replication of HBV,significantly improve liver function,and increase the numbers of CD4＋ and CD8＋ T-lymphocyte subsets in peripheral blood of patients with chronic hepatitis B.

关 键 词：慢性乙型肝炎 干扰素Α-2A T淋巴细胞亚群 

分 类 号：R512.6[医药卫生—内科学]