深圳地区3～8岁女童性早熟的临床调查  

作　　者：邹建话[1] 祝爱霞[1] 蔡叶琴[1] 陈静[1] 高水湾[1] 

机构地区：[1]广东省深圳市宝安区妇幼保健院,518133

出　　处：《浙江临床医学》2010年第8期820-822,共3页Zhejiang Clinical Medical Journal

基　　金：深圳市科技计划资助项目（No.20070265）

摘　　要：目的通过来本院体检的3～8岁女童的临床调查，试图探讨深圳地区3～8岁女童性早熟的状况。方法对4690例正常体检的3～8岁女童采用询诊、视诊、触诊，凡有单侧或双侧乳房凸起，经B超证实有乳房发育而无阴毛、腋毛发育的单纯乳房早发育女童159人，对此159例女童采用免疫化学发光方法及免疫ELISA方法检测血清中ER、N．RDH、FSH、LH的表达水平。结果各年龄段早熟女童血清中ER、N．RDH较正常女童均呈低水平表达，呵排除真性性早熟；各年龄段早熟女童血清中FSH、LH较正常组女童均呈高水平表达，证实为继发性假性性早熟。结论本临床调查证实深圳3～8岁女童存在继发性性早熟，其发生率3．8％；继发性早熟与膳食、药膳滋补密切相关。Objective To evaluate precocious puberty girls years in Shenzhen. Methods We examined girls with half or both premature thelarche in 4690, and confirmed 159 girls with no development of crinis pubis and glandebalae by using type - B ultrasonic. The expression of ER,N. RDH, FSH and LH in serum were examined by using Immunochemiluminescent and ELISA. Results （ 1 ） The expression of ER,N. RDH were lower than normal in all years of age girls, eliminating true precocious puberty. （2） The high expression of FSH, LH in serum, comparing with normal girls, confirmed secondary pseudo - precocious puberty. Conclusion The clinical study certified the age of 3 - 8 girls has a 3.8% incidence of secondary pseudo - precocious puberty in Shenzhen, which was close to their food and medical diet. The correlated department should be pay attention to this social problem in this highly developing country, and take their responsibility to make sure the food safety and Race quality.

关 键 词：女童 性早熟 雌激素受体 肾上腺素 促卵泡激素 促黄体激素 

分 类 号：R711.51[医药卫生—妇产科学]