冠心病合并2型糖尿病患者血糖、血脂水平与冠状动脉病变的关系  

The relationship of blood glucose and lipid levels with coronary lesions in patients with coronary artery disease and type 2 diabetes mellitus

作　　者：李进[1] 丁美琳[1] 苏磊[1] 

机构地区：[1]中山大学附属第一医院特诊内科,广州510080

出　　处：《国际医药卫生导报》2010年第15期1812-1814,共3页International Medicine and Health Guidance News

摘　　要：目的 探讨冠心病（CAD）合并2型糖尿病（T2DM）患者的血糖、血脂水平与冠状动脉病变之间的关系.方法 收集我院2007年1月至2009年12月期间住院行冠状动脉造影检查明确诊断为CAD患者328例,其中T2DM患者96例（糖尿病组）,非T2DM患者232例（非糖尿病组）.比较分析两组患者的空腹血糖（FBG）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、甘油三脂（TG）水平以及冠状动脉病变特点.结果 （1）糖尿病组患者FBG、TC、LDL-C以及TG水平分别为（7.2±1.1）mmol/L、（5.6±0.8）mmol/L、（3.1±0.5）mmol/L、（2.6±0.5）mmol/L,高于非糖尿病组（P＜0.05）.HDL-C水平为[0.9±0.2）mmol/L,低于非糖尿病组（P＜0.05）.（2）糖尿病组患者中冠状动脉重度狭窄者占65.6%,冠状动脉多支病变者占69.8%,明显高于非糖尿病组（P＜0.05）.（3）FBG≥6.1 mmol/L以及LDL-C≥2.6 mmol/L的CAD合并T2DM患者中冠状动脉重度狭窄者分别占73.3%、70.9%,多支病变者分别占80.0%、76.4%,高于对照组（P＜0.05）.结论 冠心病合并2型糖尿病患者冠状动脉狭窄程度重、病变分布广泛.FBG及LDL-C升高与糖尿病合并冠心病患者冠脉病变密切相关.Objective To investigate the relationship of blood glucose and lipid levels with coro-nary lesions in patients with coronary artery diease （CAD） and type 2 diabetes mellitus （T2DM）. Methods A total of 328 patients admitted to hospital from January 2007 to December 2009 and angiographically iagnosed as CAD were divided into DM group （96 eases） and non-DM group （232 eases）. The characteristics of coronary lesions and the levels of fasting blood glucose （FBG）, total cholesterol （TC）, high density lipid-cholesterol （HDL-C）, low density lipid-cholesterol （LDL-C）, and triglycerol （TG） were analyzed. Results As compared with non-DM group, levels of FBG, TC, LDL-C, and TG were higher in DM group while HDL-C levels were lower （P〈0.05）, and the coronary lesions were more severe and diffuse （P〈0.05）. As compared with the patients whose FBG was less than 6.1 mmol/L and LDL-C less than 2.6mmol/L, the coronary lesions were more severe and diffuse in those whose FBG was more than 6.1mmol/L and LDL-C more than 2.6mmol/L （P〈0.05）.Conclusions Diffuse and severe coronary lesions are more common in the patients with CAD and T2DM.The increased levels of FBG and LDL-C are closely related with the coronary lesions.

关 键 词：冠心病 2型糖尿病 血脂异常 

分 类 号：R541.4[医药卫生—心血管疾病]