聚(N,N-二烯丙基-N-丁氧羰甲基氯化铵)的合成及其杀菌性能  

Synthesis and Sterilizing Property of Poly(N,N-diallyl-N- carbobutoxymethylammonium Chloride)

作　　者：刘立华[1] 肖体乐[1] 陈金文[1] 赵艳敏[1] 刘俊峰[1] 

机构地区：[1]湖南科技大学化学化工学院,理论化学与分子模拟省部共建教育部重点实验室,分子构效关系湖南省普通高等学校重点实验室,湘潭411201

出　　处：《应用化学》2010年第8期887-892,共6页Chinese Journal of Applied Chemistry

基　　金：湖南省自然科学基金(07JJ3113);湖南省教育厅科学研究(07C287)资助项目

摘　　要：以N,N-二烯丙基-N-丁氧羰甲基氯化铵(DACBMAC)为单体,过硫酸铵为引发剂,采用水溶液聚合合成了聚(N,N-二烯丙基-N-丁氧羰甲基氯化铵)(PDACBMAC),用FT-IR和1HNMR测试技术对其结构进行了表征,并研究了其对大肠杆菌的杀菌性能和抗菌机理。结果表明,PDACBMAC对大肠杆菌的杀菌能力明显高于聚二甲基二烯丙基氯化铵(PDMDAAC),在剂量低于20mg/L时,其杀菌能力稍高于十二烷基二甲基苄基氯化铵(DDBAC);其对大肠杆菌的杀菌率随特性粘数的增加而增加,当特性粘数为1.371dL/g,剂量为30mg/L时,杀菌率可达99.7%;其杀菌效果明显受pH值影响,在pH值为4.7～6.7时,杀菌率随pH值升高而增加,pH>6.7时,其杀菌率随pH值升高而降低。浊度测定结果表明,PDACBMAC具有优良的絮凝除浊能力。β-半乳糖苷酶活性测定结果表明,PDACBMAC的抗菌机理是基于杀菌作用。Poly（N,N-diallyl-N-carbobutoxymethylammonium chloride）（PDACBMAC） was prepared from N, N-diallyl-N-carbobutoxymethylammonium chloride （ DACBMAC） as monomer and ammonium peroxydisulfate （APS） as initiator in water solution,and its structure was characterized by FT-IR and ^1H NMR. The sterilizating property of PDACBMAC against Escherichia coli（ E. coli） and its antimicrobial mechanism were also studied. The results show that the sterilizating potency of PDACBMAC against E. coli is obviously higher than that of poly （ dimethyldiallylammonium chloride ） （ PDMDAAC ） and slightly higher than that of dodecyldimethylbenzylammonium chloride（DDBAC） when the dosage is below 20 mg /L,and the bactericidal ratio is up to 99. 7% when the intrinsic viscosity of PDACBMAC is 1. 371 dL /g and the dosage is 30 mg /L. The bactericidal ratio is affected obviously by pH value,which increases with increasing pH in a range of 4. 7 ～ 6. 7,and decreases with increasing pH when pH 6. 7. The results of testing turbidity for the treated water sample show that PDACBMAC still possesses an excellent coagulation property. The results of measuring activities of the enzyme of β-D-galactosidase show that the antimicrobial mechanism of PDACBMAC is based on a sterilization action.

关 键 词：聚(N N-二烯丙基-N-丁氧羰甲基氯化铵) 杀菌性能 抗菌机理 大肠杆菌 

分 类 号：O632.6[理学—高分子化学]