三羟甲基氨基甲烷缩2-吡啶甲醛席夫碱铜配合物的合成、表征及与DNA相互作用  

Synthesis and Characterization of A New Schiff Base Copper(Ⅱ) Complex from Tris(hydroxymethyl) aminomethane and 2-Pyridinecarboxaldehyde, and Its Interaction with DNA

作　　者：杨新斌[1] 张金生[2] 陈朝晖[1] 曾仁权[1] 

机构地区：[1]西南大学荣昌校区基础部,重庆402460 [2]贵州师范大学化学与材料科学学院

出　　处：《应用化学》2010年第8期903-906,共4页Chinese Journal of Applied Chemistry

摘　　要：合成了三羟甲基氨基甲烷缩2-吡啶甲醛席夫碱铜配合物[C10H14CuN2O3]Cl2,通过元素分析、摩尔电导、红外光谱和高分辨质谱等测试技术对化合物进行了结构表征。利用电子吸收光谱、热变性和粘度实验研究了配合物与CT-DNA的相互作用,实验结果表明,该配合物以嵌插模式与DNA相互作用。A schiff base copper complex prepared through the condensation between tris （ hydroxymethyl） aminomethane and 2-pyridinecarboxaldehyde was characterized by elemental analysis,molar conductance,IR and HRMS. The interaction of the complex with culf thymus （ CT-DNA） was investigated by UV spectra, viscosity measurements and DNA thermal denaturation experiments. The experimental results show that the mode of the complex bound to DNA is intercalation.

关 键 词：铜配合物 小牛胸腺DNA 嵌插 

分 类 号：O611.6[理学—无机化学]