肾内感受器对家兔心功能的影响及电针效应  

Effect and Electro Acupuncture Response of the Renal Mechanoreceptors on the Cardiac Function in Rabbits

作　　者：孙鲁申[1] 马正行[1] 蔡乃真 王引华 张天红[1] 

机构地区：[1]上海铁道大学医学院生理教研室

出　　处：《上海针灸杂志》1999年第2期31-33,共3页Shanghai Journal of Acupuncture and Moxibustion

摘　　要：目的探讨肾内感受器在缓冲神经完整与否的情况下对心功能的影响及其电针效应。方法采用２３只麻醉家兔，以心肌力学参数为指标，观察肾盂内加压刺激家兔肾内机械感受器对心功能的影响及其电针效应。结果在神经完整组（Ａ组ｎ＝１５）和去缓冲神经组（Ｂ组ｎ＝８），当以梯度压力刺激肾机械感受器时，室内压最大值（ｐｅａｋｖｅｎｔｒｉｃｕｌａｒｐｒｅｓｓｕｒｅＰＶＰ）、舒张末期室内压（ＥＤＰ）、室内压最大变化速率（±ｄｐ／ｄｔｍａｘ）、心肌收缩成分的缩短速度（Ｖｃｅ）、心力环面积（Ｌｏ）等各项心肌力学指标均下降（Ｐ＜０．００１），Ｂ组下降更为明显（Ｐ＜０．００１），呈压力－效应关系。在电针肾俞穴后，两组的心肌力学指标抑制均更为显著（Ｐ＜０．００１）。结论激活肾内感受器对家兔心功能呈抑制反应；动脉压力感受性反射具有缓冲肾传入冲动对心功能的抑制作用；Objective To observe the effect and electro acpuncture response of the renal mechanoreceptors on the cardiac function in rabbits. Method Observations were made of the effect of the elevated ureteral pressure and stimulated the renal mechanoreceptor on the cardiac function in 23 anaesthetized rabbits under the guidance of myocardial mechanics and response to the electro acupuncture. Result The results indicate that the various parameters of myocardial mechanics such as PVP 1, EDP, ±dp/dt max , Vce, Lo all decline ( P <0.001). When gradient pressure stimulated the renal mechanoreceptors in the nerve intact group (Group A n=15) and the buffer nerve removed group (Group B n=8), the decline of Group B being more obvious ( P <0.001) and shows the pressure response relationship. After the electro acupuncture on the “Shen shu” point, the cardiac function of both group were inhibited significantly ( P <0.001). Conclusion These studies suggest that the activation of the renal receptors results in inhibting the cardiac function; The arterial baroreceptor reflex plays a buffering role in the cardiovascular responses to the renal afferent impulses; The application of the electro acupuncture on the “shen shu” point might increase inhibitory response mentioned above.

关 键 词：机械感受器 电针 俞肾穴 心功能 

分 类 号：R245[医药卫生—针灸推拿学] R224.2[医药卫生—中医临床基础]