运动对自发性高血压大鼠心肌血管内皮生长因子及其基因表达的影响  

Effct of Exercise on Expression of Vascular Endothelial Growth Factor and its Gene in Myocardium or SHR

作　　者：李维根[1] 李昭波[1] 高云秋[1] 唐朝枢[2] 

机构地区：[1]北京医科大学第三医院运动医学研究所,北京100083 [2]北京医科大学心血管基础研究所

出　　处：《中国运动医学杂志》1999年第2期115-116,共2页Chinese Journal of Sports Medicine

摘　　要：为探讨血管内皮生长因子（Ｖａｓｃｕｌａｒ　ｅｎｄｏｔｈｅｌｉａｌ　ｇｒｏｗｔｈ　ｆａｃｔｏｒ，ＶＥＧＦ）是否参与运动改善高血压性心肌肥大机制，采用免疫组化和分子杂交方法，研究了自发性高血压大鼠（ｓｐｏｎｔａｎｅｏｕｓｌｙ　ｈｙｐｅｒｔｅｎｓｉｖｅ　ｒａｔｓ，ＳＨＲ）游泳运动后心肌细胞ＶＧＥＦ及其基因表达的改变。免疫组化结果表明，ＳＨＲ经１０周游泳后，心肌细胞浆内ＶＥＧＦ特异染色颗粒比安静ＳＨＲ明显增多。Ｎｏｒｔｈｅｍ分子杂交结果表明，ＳＨＲ运动后心肌ＶＥＧＦ　ｍＲＮＡ表达比安静ＳＨＲ降低。目前对这一结果的生理意义还不清楚，推测可能与改善高血压肥大心肌间质血管增生机制有关。To identify the effect of vascular endothelial growth factor(VEGF)on exercise-induced hypertrophied heart,we studied the expression alter- ation of VEGF and its gene in myocardium of spontaneously hypertensive rats(SHR)swimming for 10 weeks compared with matched control SHR, stronger intracelluar VEGF immunoractivity and decreased expression of VEGF mRNA were Present in swimming SHR myocardium by immunohistochemistry assay and Northern blot experimens..Although little is known about the role of VEGF and its gene expression downgu- lation in SHR myocardium,it seems reasonable to vascular proliferation in hypertensive hypertrophic heart.

关 键 词：心肌以大 高血压 基因表达 运动 VEGF 

分 类 号：R544.1[医药卫生—心血管疾病] G804.3[医药卫生—内科学]