原发性高血压患者中医辨证分型与ACE基因I/D多态性的相关性研究  

Relationship between polymorphism of angiotensin converting enzyme gene and different traditional Chinese medicine syndrome in patients with essential hypertension

作　　者：董昌武[1] 董梅[1] 邢齐树[1] 黄开泉[1] 周雪梅[1] 陈雪功[1] 

机构地区：[1]安徽中医学院中医临床学院,安徽合肥230038

出　　处：《中国病理生理杂志》2010年第8期1545-1548,共4页Chinese Journal of Pathophysiology

基　　金：安徽省科技厅自然科学基金年度重点科研计划资助项目(No.7020303078);安徽省教育厅自然科学基金重点资助项目(No.kj2007A036)

摘　　要：目的:探讨原发性高血压不同中医证型与血管紧张素转换酶(ACE)基因多态性分布的相关性。方法:选择原发性高血压患者120例,中医辨证分型为肝火旺盛型、阴虚阳亢型、阴阳两虚型、痰湿壅盛型,选取正常对照组30例,并采用PCR方法检测ACE基因的多态性。结果:ACE基因DD型在阴虚阳亢组与正常对照组之间显著差异(P<0.05),而ACE基因Ⅱ、ID型及等位基因与正常对照组比较无显著差异(P>0.05)。各证型组之间两两比较ACE基因型和等位基因之间都无显著差异(P>0.05)。结论:原发性高血压阴虚阳亢型可能与ACE基因DD型有关联。AIM： To study the distribution of angiotensin converting enzyme（ACE） gene I/D polymorphism and its relationship with various traditional Chinese medicine（TCM） syndromes in patients with essential hypertension.METHODS： 120 individuals with essential hypertension were involved and classified into liver-fire hyperactivity（LFH） syndrome,yin-deficiency and yang-hyperactivity（YDYH） syndrome,yin-yang deficiency（YYD） syndrome and sputum-dampness retention（SDR） syndrome based on the syndrome differentiation of TCM,while 30 normal individuals served as the control group.The polymerase chain reaction（PCR） was used to test ACE I/D polymorphism.RESULTS： The ACE gene DD genotype in yin-deficiency and yang-hyperactivity syndrome was markedly higher than that in control group（P0.05）.There was no significant difference in ACE gene II,ID genotypes and alleles between patients with hypertension and normal controls（P0.05）.There was no difference in ACE genotype and allele among different TCM syndromes in patients with essential hypertension（P0.05）.CONCLUSION： The DD genotype of ACE polymorphism is associated with yin-deficiency and yang-hyperactivity syndrome in patients with essential hypertension.

关 键 词：原发性高血压 ACE基因I/D多态性 中医辨证 

分 类 号：R544.1[医药卫生—心血管疾病]