肾上皮细胞损伤对草酸钙形成和黏附的影响  

Effect of Renal Epithelial Cell After Injury on Biomineralization of Calcium Oxalate

作　　者：欧阳健明[1] 杨如娥[1] 谈金[1] 

机构地区：[1]暨南大学生物矿化与结石病防治研究所,广州510632

出　　处：《化学进展》2010年第8期1665-1671,共7页Progress in Chemistry

基　　金：国家自然科学基金项目(No.20971057)资助

摘　　要：肾结石是病理性生物矿化的产物,其主要矿物为草酸钙。肾小管上皮细胞(REC)损伤在肾结石形成过程中起着关键作用。本文综述了REC损伤后膜表面表达的功能分子,特别是可促进晶体黏附的含酸性基团分子,包括磷脂酰丝氨酸、透明质酸、骨桥蛋白、跨膜糖蛋白等;从分子和超分子水平上讨论了这些功能分子调控草酸钙成核、生长和黏附的机理及其影响因素;并提出了今后的研究方向。Kidney stone is the production of pathologic biomineralization,with calcium oxalate（CaOxa） as the main mineral component.The injury of renal tubular epithelial cell（REC） plays an important role in the development of kidney stone.In this review,it is summarized that the functional molecules on the surface of membrane of the injured cells,especially the molecules containing acidic groups which promoting crystal adhesion.These functional molecules include phosphatidylserine,hyaluronic acid,osteopontin,and transmembrane glycoprotein,etc.The mechanism and influence factors of these functional molecules on regulation of nucleation,growth and adhesion of CaOxa are discussed at the molecular level.The research direction is also indicated.

关 键 词：生物矿化 草酸钙 晶体黏附 肾结石 细胞调控 

分 类 号：R691.4[医药卫生—泌尿科学] O611.6[医药卫生—外科学]