新诊断2型糖尿病患者血浆内脂素水平变化研究  

Change of Plasma Visfatin Level in Patients with Newly Diagnosed Type 2 Diabetes Mellitus

作　　者：王学群[1] 胡燕明[1] 李强[1] 林茂华[1] 蔡伟雄[1] 

机构地区：[1]广东省博罗县人民医院内科,516100

出　　处：《实用心脑肺血管病杂志》2010年第9期1212-1213,共2页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

摘　　要：目的探讨新诊断2型糖尿病(T2DM)患者血浆内脂素水平变化。方法检测113例新诊断T2DM患者和102例正常对照的空腹血浆内脂素水平和相关临床指标。结果新诊断T2DM患者血浆内脂素水平高于正常对照组(P<0.05)。多重线性回归分析显示腰臀比和空腹血糖是影响血浆内脂素水平的独立相关因素。结论血浆内脂素水平变化与糖代谢密切相关,它可能在T2DM的发病机制中起着一定作用。Objective To investigate whether plasma visfatin level is altered in patients with newly diagnosed type 2 diabetes mellitus（T2DM）.Methods Plasma visfatin concentrations and some clinical characteristics were measured in 113 patients with newly diagnosed T2DM and 102 normal control subjects.Results Plasma visfatin was found to be elevated in patients with newly diagnosed T2DM（P〈0.05）.In a multiple linear regression analysis,only waist to hip ratio（WHR） and fasting plasma glucose（FPG） were independently associated with plasma visfatin level.Conclusion The change of plasma visfatin level is associated with glucose metabolism,which may play a role in the pathogenesis of T2DM.

关 键 词：脂肪细胞因子 内脂素 2型糖尿病 

分 类 号：R587.1[医药卫生—内分泌]