细胞因子信号转导抑制蛋白3与骨髓增殖性肿瘤关系的研究进展  

Research Advances on Relationship between Suppressor of Cytokine Signaling 3 and Myeloproliferative Neoplasms——Review

作　　者：秦伟[1] 

机构地区：[1]上海同济大学医学院同济医院血液科,上海200065

出　　处：《中国实验血液学杂志》2010年第4期1101-1104,共4页Journal of Experimental Hematology

基　　金：国家自然科学基金资助项目;编号30572161

摘　　要：细胞因子信号转导抑制蛋白(suppressor of cytokine signaling,SOCS)是一类对细胞因子和生长相关因子信号转导通路起负性调节的蛋白家族,目前已发现20多个成员,其中SOCS3是该家族中研究最热、最为清楚的成员之一。近年来研究发现,骨髓增殖性肿瘤(myeloproliferative neoplasms,MPN)患者中存在SOCS3基因异常,提示其可能在MPN的发生、发展、转移过程中扮演重要角色。本文就SOCS3与MPN关系的研究进展进行综述,讨论的问题主要包括有:SOCS蛋白家族概况,SOCS3的结构,功能,表达与调控,以及COCS3与MPN的关系等。Suppressor of cytokine signaling （SOCS） is a protein family negatively regulating signal transduction pathway of a certain class of cytokines and growth factors. More than 20 members have been found in SOCS family, SOCS3 is one of them and has been studied hottest and most clearly. Recent studies demonstrated that SOCS3 abnormalities were found in patients with myeloproliferative neoplasms （MPN）, suggesting that SOCS3 plays a significant role in the pathogenesis, development and metastasis in MPN. In this review, the advances of research on relationship between SOCS3 and MPN were summarized, including general profile of SOCS family; structure, function and regulation of SOCS3, relation of SOCS3 to MPN and so on.

关 键 词：细胞因子信号转导蛋白抑制因子-1 细胞因子 信号传导 骨髓增殖性疾病 

分 类 号：R551.3[医药卫生—血液循环系统疾病]