光动力疗法治疗残胃复发癌的远期疗效  

Long-term Effect of Photodynamic Therapy for Recurrent Gastric Cancer

作　　者：毛永平[1] 邱海霞[2] 顾瑛[2] 王颖[2] 曾晶[2] 刘庆森[1] 杨云生[1] 

机构地区：[1]中国人民解放军总医院消化科,北京市100853 [2]中国人民解放军总医院激光医学科,北京市100853

出　　处：《中国激光医学杂志》2010年第3期156-159,共4页Chinese Journal of Laser Medicine & Surgery

摘　　要：目的评价光动力疗法治疗残胃复发癌的远期疗效。方法胃癌术后残胃复发癌患者1例,于2000～2005年间先后进行4次光动力治疗。静脉推注光敏剂5mg/kg(前3次为HpD,第4次为PSD-007)后36～48h,在胃镜下应用金蒸气激光(波长627.8nm)以点状光纤进行照射,激光功率密度为100～200mW/cm2,照光时间20～30min,能量密度为120～360J/cm2。术后定期复查胃镜和长期随访,进行近期及远期疗效评价。结果术后4～5周胃镜及病理学检查局部癌灶消失,随访5～10年胃镜及病理检查均未发现局部肿瘤复发。术中及术后未见不良反应发生。结论光动力疗法对残胃复发癌是一种安全、有效、可以重复进行的微创治疗,不破坏组织器官的功能和完整性,能明显改善患者的生活质量,远期疗效较好。Objective To observe the long-term effect of photodynamic therapy for recurrent cancer of gastric stump.Methods The PSD-007 or HpD at 5 mg/kg body weight for 36-48 hours was intravenously injected.According to the different sites of cancer recurrence in the gastric stump,the patient was irradiated with a gold vapor laser using a point-like optical fiber （627.8 nm of wavelength,power density of 100-200 mW/cm^2,irradiation time of 20-30 minutes and light dose of 120-360 J/cm^2）.Endoscopy and pathological examination were conducted to evaluate the short-term and long-term effect of PDT.ResultsPDT was conducted at the site of cancer recurrence of each time.Endoscopic examination and pathological examination found no tumor cells at 4-5 weeks after PDT.Endoscopy and pathological examination at 5 to 10 years following up revealed no cancer recurrence at treatment area.No adverse events were seen during and after PDT.ConclusionsPDT is a safe,effective and minimally invasive treatment for recurrent cancer of gastric stump.PDT can be repeated to use without disturbance of the function and integrity of target organ,and can significantly improve patient＇s quality of life with good long-term effect.

关 键 词：光动力疗法 残胃 复发癌 

分 类 号：R454.2[医药卫生—治疗学] R735.2[医药卫生—临床医学]