再生障碍性贫血患儿免疫状况及其外周血IL-2活性水平的研究  

IMMUNOLOGICAL STATUS AND INTERLEUKIN-2 OF PERIPHERAL BLOOD LEUKOCYTES IN CHILDHOOD APLASTIC ANEMIAS

作　　者：应大明[1] 穆宏华[1] 林梓[1] 王跃平 周昕[1] 钱龙华[1] 姚慧玉[1] 薛惠良[1] 谢晓恬 

机构地区：[1]上海第二医科大学上海市儿科研究所新华医院,200092

出　　处：《上海免疫学杂志》1990年第3期151-155,共5页Shanghai Journal of Immunology

摘　　要：本文对13例小儿再障的细胞免疫状况及T淋巴细胞亚群和外周血淋巴细胞诱生的白细胞介素-2(IL-2)活力进行测定。其中3例作免疫治疗前后的动态比较。结果显示患儿总T 细胞(CD_3)及T辅助细胞(CD_4)均低于正常儿,而T抑制细胞(CD_8)则高于正常儿,使CD_4/CD_8的比值明显低于正常儿(0.91±0.46:1,正常儿1.67±0.24:1,P<0.01)。而IL-2活性在患儿白细胞中高于正常高限(529.76±±36.84比316.31±53.99,P<0.01),说明患儿有免疫紊乱状态。应用免疫抑制治疗(ATG,环孢素A等),可纠正这种不平衡状态,临床也有良好的效应。Immunologic status (distribution of T-cell subgroups and IL-2 activity induced by peripheral monocytes) was investigated in 13 cases of childhood aplastic anemia. In the diseased children, readings of CD3 and CD4 were higher with CD8 lower than those in the controls, resulting in a significantly lowered CD4/CD8 ratio (0.91 ± 0.46 VS 1. 67 ± 0.24, p<0.01). The mean level of IL-2 activity was significantly increased (529. 76 ± 36.84u/mlVS 316.31 ± 53.99 u/ml, p<0.01). These immunologic disturbances were corrected in all the 4 patients receiving immuno-suppressive therapy (2 cases with ATG and 2 cases with CSA) with satisfactory remissions.

关 键 词：再生障碍性 儿童 免疫 贫血 

分 类 号：R556.503[医药卫生—血液循环系统疾病]