地塞米松对氟比洛芬酯镇痛作用影响的临床观察  

Clinical observation of the postoperative analgesic effect when dexamethasone is added to flurbiprofen axetil

作　　者：陈琦[1] 薄玉龙[1] 

机构地区：[1]黑龙江哈尔滨医科大学附属第二医院麻醉科.151000

出　　处：《医学信息（下旬刊）》2010年第8期51-52,共2页Medical information

摘　　要：目的：观察不同剂量地塞米松对氟比洛芬酯镇痛作用的影响。方法：选择80例择期于全麻下行乳癌根治手术病人，年龄20～60岁，ASAⅠ～Ⅱ级。随机双盲分为四组，每组20例。A组于麻醉诱导后静脉注射等量生理盐水，B组静脉注射地塞米松5mg，C组静注地塞米松10mg，D组静注地塞米松15mg．所有患者均于手术开始前10min静注氟比洛酯1mg／kg。手术结束前10min给予芬太尼1μg／kg，术后患者感到疼痛时给予曲马多1mg／kg。观察停药后患者的清醒时间、拔管时间、术后72h镇痛评分及不良反应的发生情况。结果：四组病人术后8小时疼痛评分无显著性差异，24～72h后C组及D组镇痛效果明显好于A、B两组，VSA评分有显著性差异P〈0．05，术后四组病人不良反应发生无显著性差异。结论：地塞米松可以延长氟比洛芬酯的镇痛效果，且在24至72小时期间作用表现明显。Objects：To observe the analgesia effect when different dose dexamethasone is added to fllurbiprofen axetil. Methods： Eighty ASA Ⅰ～Ⅱ and aging 20~60 years old patients undergoing the general anesthesia downward breast surgery are randomly divided into four groups. The C group inject isometric physiological saline after anesthesia intubation, the B group inject 5mg dexamethasone, the C group inject 10mg dexamethasone, the D group inject 15mg dexamethasone,all patients inject 1mg/kg flurbiprofen before 10 minutes the operation start. Injecting 1μg/kg fentanil before 10 minutes the operation end,post--operation inject axeyii（1mg/kg） when pain. Observing consciousness time, extubation time,VAS scale of postoperation 72h and adverse reaction. Results：Four groups patients have not statistics significance in VAS of postoperation 8h, the analgesia effect of C group and D group were better than A group and B group from postoperation 24h to 72h,the VAS scale have statistics significance（P〈0.05） ,four groups have not statistics significance in adverse reaction. Conclusion： dexamethasone can prolong the analgesia effect of flurbiprofen, and better in postoperation 24h~ 72h.

关 键 词：地塞朱松 氟比洛芬酯 镇痛 

分 类 号：R971[医药卫生—药品]