PolyI:C_(12)U对甲型流感病毒感染小鼠保护作用的观察  

STUDY ON THE PROTECTIVE ROLE OF POLYI: C_(12)U IN MICE INFECTED WITH INFLUENZA A VIRUS

作　　者：何有成[1] Micheal Kulka Paul O.P.TS'o 罗章炎 彭文伟[1] 

机构地区：[1]中山医科大学传染病学教研室,广州510630 [2]美国霍布金斯大学生物物理实验室

出　　处：《上海免疫学杂志》1990年第6期324-327,共4页Shanghai Journal of Immunology

摘　　要：本文观察了 PolyI:C(聚肌胞)的错配体PolyI:C_(12)U对感染致死剂量甲型流感病毒小鼠的保护效果。在病毒感染前先给予2次 PolyI:C_(12)U(5μg/g·次)腹腔内注射,并在病毒感染后连续用药,可明显推迟小鼠肺炎的出现时间,减轻肺部病变严重程度并使小鼠死亡率降低到50％以下。推测 PolyI:C_(12)U 的抗病毒作用可能与体内干扰素的诱生和自然杀伤细胞活性增强有关。The protective role of PolyI:C12U (the mismatched analogue of PolyI:C) in mice intranasally inoculated with a lethal dose of influenza A virus was studied. Intraper-itoneal administration of 2 doses (5 μg/g/dose) of PolyI:C12U at 48 hours intervals before the virus inoculation and additional 6 to 12 doses at 24 hours intervals post infection could overtly delay the appearance of influenzal pneumonia, reduce the severity of the lung lesions and decrease the mortality rate of the infected mice to less than 50%. It is assumed that the antiviral effects of PolyI:C12U may be associated with its ability to induce interferon (IFN) production and the enhancement of natural killer (NK) cell activity.

关 键 词：聚肌胞 甲型流感病毒 保护作用 

分 类 号：R978.7[医药卫生—药品]