全身组织器官胰岛素抵抗的研究进展  

Research Progress on Insulin Resistance of Multiple Organs and Tissues

作　　者：陈秋伶[1] 肖常青[1] 庞翠军[1] 

机构地区：[1]广西医科大学第一附属医院代谢糖尿病中心,南宁530021

出　　处：《医学综述》2010年第16期2407-2410,共4页Medical Recapitulate

基　　金：广西科学自然基金(桂科自0832122);广西医疗卫生自筹经费计划课题(Z2009093)

摘　　要：胰岛素抵抗为2型糖尿病和代谢综合征的基本病理生理基础。除了经典的胰岛素作用的靶器官(如肝脏、脂肪和骨骼肌)外,随着研究的深入,近年来还发现血管内皮细胞、脑、胰岛的β细胞以及胰岛α细胞等新的胰岛素作用靶组织,肾素-血管紧张素系统也与胰岛素抵抗密切相关。全身多组织器官的参与,使胰岛素抵抗的机制更加复杂化。Insulin resistance is the basic pathophysiology of type 2 diabetes and metabolic syndrome.The classic insulin target organs are liver,adipose tissue and skeletal muscle.Many new insulin target tissues have been found in recent years due to the development of research in endothelial cells,brain,islet beta cells and alpha cells,even the renin-angiotensin system which are also closely related with insulin resistance.The involvement of multiple organs and tissues makes the mechanism of insulin resistance more complicated.

关 键 词：胰岛素抵抗 组织器官 交谈 

分 类 号：R587.1[医药卫生—内分泌]