T-bet在肺结核组织淋巴细胞中的表达特征及其临床意义  

Expression levels of T-bet in the lung tissues lymphocytes of patients with tuberculosis and its role in clinic

作　　者：苟继周[1] 王正[2] 杨林[2] 乐晓华[1] 廖明凤[1] 杨桂林[1] 陈心春[1] 付向东[1] 

机构地区：[1]深圳市第三人民医院,广东深圳518020 [2]深圳市人民医院

出　　处：《临床肺科杂志》2010年第9期1244-1245,共2页Journal of Clinical Pulmonary Medicine

基　　金：国家十一五科技重大专项(2008ZX10003-012);深圳市科技计划项目(200802056)

摘　　要：目的探讨肺结核组织中T-bet的表达与机体免疫和病理发展变化的关系。方法采用免疫组织化学双染法检测8例肺结核组织中T-bet和CD4+、CD20+的表达情况。结果在肺结核结节中,CD4+T细胞T-bet阳性率为70.1%,CD20+B细胞T-bet阳性率为18.2%。结论 T-bet在肺结核组织中高表达,T-bet在肺结核的机体免疫中可能发挥着重要的作用。Objective To study the relationship between expression level of T-bet in patient with tuberculosis and their immune system and pathological variation.Methods Expression profile of T-bet and CD4,CD20 was stained in lung tissues from eight cases with tuberculosis by immunohistochemistry（double staining method）.Results In tuberculosis nodules tissue,the positive rate of T-bet＋were 70.1%in CD4^＋T cells,and 18.2%in CD20^＋B cell.Conclusion The over expression of T-bet in lung tissues may play an important role in immune responses of patients with tuberculosis.

关 键 词：肺结核 免疫组织化学 T-BET 

分 类 号：R521[医药卫生—内科学]