冠心病患者HSP70-2+1267A/G多态性与高敏C反应蛋白水平的相关性研究  

The Relationship between Heat-Shock Protein 70-2 Gene+1267A/G Polymorphism and Serum Level of High Sensitivity C-Reactive Protein in Patients with Coronary Artery Disease.

作　　者：段成城[1] 陈倩[1] 王方剑[1] 江勇[1] 潘小华[1] 郑美梅[1] 董丽妍[1] 温武金[1] 

机构地区：[1]广州医学院附属深圳沙井医院,广东深圳518104

出　　处：《心脑血管病防治》2010年第4期267-269,共3页CARDIO-CEREBROVASCULAR DISEASE PREVENTION AND TREATMENT

基　　金：深圳市宝安区科技局基金资助(No2009336)

摘　　要：Objective To explore the relationship between heat-shock protein 70-2 gene +1267A/G polymorphism(HSP70-2 gene +1267A/G polymorphism) and serum level of high sensitivity C-reactive protein(Hs-CRP) in patients with coronary artery disease(CAD).Methods Serum Hs-CRP level and HSP70-2 gene +1267A/G polymorphism were detected in 185 patients with CAD.HSP70-2 gene +1267A/G polymorphism was screened by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP).Results The genotype distribution of the HSP70-2 gene +1267A/G polymorphism was as follows: AA was in 24 of 185 patients(12.97%),AG in 93 of 185 patients(50.27%) and GG in 68 of 185 patients(36.76%).Patients with GG、AG subtype had higher Hs-CRP levels compared with carriers of the AA subtype(4.5±1.8mg/L,3.2±1.2mg/L and 2.7±1.1mg/L,respectively,P<0.05).Among patients who had Hs-CRP >3mg/L,GG,and AG gene subtypes had higher percentage than A allele homozygotes(92.6%,74.2% and 45.8%,respectively.χ2=17.75,28.04,P<0.05).Conclusions This study indicated G allele of HSP70-2 gene +1267A/G polymorphism may be an independent risk factor in systemic inflammation with stable CAD.Objective To explore the relationship between heat-shock protein 70-2 gene ＋1267A/G polymorphism（HSP70-2 gene ＋1267A/G polymorphism） and serum level of high sensitivity C-reactive protein（Hs-CRP） in patients with coronary artery disease（CAD）.Methods Serum Hs-CRP level and HSP70-2 gene ＋1267A/G polymorphism were detected in 185 patients with CAD.HSP70-2 gene ＋1267A/G polymorphism was screened by polymerase chain reaction-restriction fragment length polymorphism（PCR-RFLP）.Results The genotype distribution of the HSP70-2 gene ＋1267A/G polymorphism was as follows： AA was in 24 of 185 patients（12.97%）,AG in 93 of 185 patients（50.27%） and GG in 68 of 185 patients（36.76%）.Patients with GG、AG subtype had higher Hs-CRP levels compared with carriers of the AA subtype（4.5±1.8mg/L,3.2±1.2mg/L and 2.7±1.1mg/L,respectively,P〈0.05）.Among patients who had Hs-CRP 3mg/L,GG,and AG gene subtypes had higher percentage than A allele homozygotes（92.6%,74.2% and 45.8%,respectively.χ^2=17.75,28.04,P〈0.05）.Conclusions This study indicated G allele of HSP70-2 gene ＋1267A/G polymorphism may be an independent risk factor in systemic inflammation with stable CAD.

关 键 词：冠心病患者 冠状动脉粥样硬化斑块 蛋白水平 相关性 C反应 多态性 Protein ARTERY 

分 类 号：R541.4[医药卫生—心血管疾病]