杭州市部分职业人群血清非高密度脂蛋白胆固醇水平分析  

Investigation of Serum Non-high Density Lipoprotein Cholesterol in Hangzhou Occupational Population.

作　　者：于小妹[1] 谢海宝[1] 毕其华[1] 沈世恩[1] 

机构地区：[1]浙江医院,浙江杭州310013

出　　处：《心脑血管病防治》2010年第4期272-274,共3页CARDIO-CEREBROVASCULAR DISEASE PREVENTION AND TREATMENT

摘　　要：Objective To observe the serum level of non-high density lipoprotein cholesterol(non-HDLC),and to evaluate the relationship between non-HDLC and atherosclerosis in Hangzhou occupational population.Methods 11668 people(7369 males,4299 females) who took physical examination in our hospital during 2006.1-2007.6 were detected the fast serum levels of total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDL-C) and low density lipoprotein cholesterol(LDL-C) according to standard operating procedure.And then non-HDLC and atherogenic index of plasma(AIP) were calculated according to the formulae non-HDL-C =TC-HD-C and AIP=log(TG/HDL-C).Statistical analysis was performed to evaluate the correlation between non-HDLC and atherosclerosis.Results There was a significant difference of LDL-C between by direct assay and by Friedewald formula calculation(P<0.001).When TG<4.5mmol/L and TG without grouping,LDL-C calculated by Friedewald formula was higher than that by direct assay.When TG≧4.5mmol/L,LDL-C calculated by Friedewald formula was obviously lower than that by direct assay.Non-HDLC was more closely related to AIP than LDLC as comparing TC and TG on different levels.Conclusions Non-HDLC was more closely related to AIP,and it could be used to judge the chanciness of atherosclerosis.Therefore,we suggest that the value of non-HDLC and AIP should be combined on analyzing routine blood fat to elevate the accuracy of artherosclerosis evaluation and non-HDLC as the second target in blood fat treatment.Objective To observe the serum level of non-high density lipoprotein cholesterol（non-HDLC）,and to evaluate the relationship between non-HDLC and atherosclerosis in Hangzhou occupational population.Methods 11668 people（7369 males,4299 females） who took physical examination in our hospital during 2006.1-2007.6 were detected the fast serum levels of total cholesterol（TC）,triglyceride（TG）,high density lipoprotein cholesterol（HDL-C） and low density lipoprotein cholesterol（LDL-C） according to standard operating procedure.And then non-HDLC and atherogenic index of plasma（AIP） were calculated according to the formulae non-HDL-C =TC-HD-C and AIP=log（TG/HDL-C）.Statistical analysis was performed to evaluate the correlation between non-HDLC and atherosclerosis.Results There was a significant difference of LDL-C between by direct assay and by Friedewald formula calculation（P〈0.001）.When TG〈4.5mmol/L and TG without grouping,LDL-C calculated by Friedewald formula was higher than that by direct assay.When TG≧4.5mmol/L,LDL-C calculated by Friedewald formula was obviously lower than that by direct assay.Non-HDLC was more closely related to AIP than LDLC as comparing TC and TG on different levels.Conclusions Non-HDLC was more closely related to AIP,and it could be used to judge the chanciness of atherosclerosis.Therefore,we suggest that the value of non-HDLC and AIP should be combined on analyzing routine blood fat to elevate the accuracy of artherosclerosis evaluation and non-HDLC as the second target in blood fat treatment.

关 键 词：非高密度脂蛋白 胆固醇水平 极低密度脂蛋白胆固醇 职业人群 杭州市 致动脉粥样硬化 血清 降脂治疗 

分 类 号：R446.1[医药卫生—诊断学]