儿童产超广谱β-内酰胺酶细菌感染耐药性研究  

Antimicrobial resistance of extended-spectrum beta-lactamase-producing bacterial infection in children

作　　者：白丽霞[1] 李霞[1] 周慧[1] 张小娜[1] 赵东蔼[1] 

机构地区：[1]山西省儿童医院,山西太原030013

出　　处：《中国感染控制杂志》2010年第4期267-268,271,共3页Chinese Journal of Infection Control

基　　金：山西省科技厅攻关项目(051099-1)

摘　　要：目的比较儿童送检标本分离的产超广谱β-内酰胺酶(Extended-spectrum beta-1actamase,ESBLs)细菌的耐药性,为临床抗ESBLs菌株感染治疗提供参考依据。方法抽取山西省儿童医院2007年1月-2009年4月各类送检标本分离的ESBLs阳性和阴性菌株各100株进行耐药性比较。结果 200株菌株对亚胺培南全部敏感;而对其他11种抗菌药物的耐药性,ESBLs阳性菌株均高于ESBLs阴性菌株(P≤0.001)。其中ESBLs阳性菌株除对头孢哌酮/舒巴坦的耐药率较低(13.00%)外,对其余头孢类抗生素的耐药率均>98%;对庆大霉素和环丙沙星的耐药率分别高达69.07%和59.18%。结论儿童分离的ESBLs阳性菌对碳青霉烯类或加酶抑制剂复合抗菌药物(如头孢哌酮/舒巴坦)较敏感。Objective To study the antimicrobial resistance of extended spectrum bets-lactamase（ESBLs）-producing bacteria isolated from children, so as to provide reference for treating infections with ESBLs-produeing bacteria. Methods One hundren ESBLs-producing strains and 100 non-ESBLs-producing strains were randomly selected from Children＇s Hospital of Shanxi Province between January 2007 and April 2009, and their antimicrohial resistance were campared. Results All 200 strains were sensitive to imipenem; the resistance of ESBLs-positive strains to the other 11 kinds of antimicrohial agents were higher than that of ESBLs-negative strains （P〈0. 001）. Except resistance to cefoperazone/sulbactam was low （13. 00%）, the resistance of ESBLs positive strains to the other cephalosporins were all〉98% ; The resistant rate to gentamycin and ciprofloxacin was 69.07 % and 59.18 respectively. Conclusion ESBLs-producing strains isolated from children are sensitive to earbapenems or antimicrobial compound inhibitors （such as cefoperazone/sulbactam）.

关 键 词：超广谱Β-内酰胺酶 抗药性 微生物 儿童 大肠埃希菌 肺炎克雷伯菌 

分 类 号：R969.3[医药卫生—药理学]