sOX40L对急性冠脉综合征诊断价值的探讨  

The Significance of sOX40L in the Diagnosis of Acute Cronary Sndrome

作　　者：彭朝权[1] 吴晓[1] 邹丽媛[1] 李翠芝[1] 刘金来[1] 赵长林[1] 

机构地区：[1]中山大学附属第三医院心内科,广东广州510630

出　　处：《中国误诊学杂志》2010年第23期5545-5547,共3页Chinese Journal of Misdiagnostics

摘　　要：目的探讨血浆可溶性OX40L(sOX40L)的水平在急性冠脉综合征(ACS)中的意义及与C反应蛋白(CRP)和血脂的关系。方法按照WHO关于冠心病的诊断标准,并结合冠状动脉造影结果,选择急性心肌梗死(AMI)组25例,不稳定心绞痛(UA)组24例,稳定型心绞痛(SA组)22例,对照组18例。采用酶联免疫吸附法(ELISA)测定标本中的sOX40L水平,并同时测定CRP、血清总胆固醇(TC)、甘油三脂(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)。结果 AMI组sOX40L水平[(14.18±2.75)ng/ml]和UA组sOX40L水平[(13.02±2.92)ng/ml]明显高于SA组[(7.57±2.12)ng/ml]和对照组[(7.77±2.04)ng/ml](P<0.01);sOX40L与CRP,TC/HDL-C均呈显著正相关,与HDL-C呈负相关。结论 AMI和UA组血浆中sOX40L水平明显高于SA组和对照组,且与炎症标志物CRP以及血脂TC/HDL-C呈显著正相关,提示sOX40L有可能作为ACS早期预测的参考指标。Objective To evaluate the significance of plasma soluble OX40 ligand（sOX40L） level in the patients with acute coronary syndrome（ACS） as well as the relationship between sOX40L and C-reactive protein（CRP）,blood lipid.Methods According to WHO diagnostic criterion of coronary heart disease（CHD） and the results of coronary angiography（CAG）,25 cases in acute myocardial infarction（AMI）,24 cases in unstable angina（UA）,22 cases in stable angina（SA） group and 18 cases of non-CHD（NCHD） were selected.The sera levels of sOX40L in four groups were detected with the enzyme-linked immuneosorbent assay（ELISA）（ng/ml）.The CRP,total cholesterol（TC）,triglyceride（TG）,high-density lipoprotein cholesterol（HDL-C） and low-density lipoprotein cholesterol（LDL-C） were detected at the same time.Results The levels of sOX40L in AMI[（14.18±2.75） ng/ml] and UA [（13.02±2.92） ng/ml] were higher than those of the SA [（7.57±2.12） ng/ml,P0.01] and the NCHD [（7.77±2.04） ng/ml,P0.01].The levels of sOX40L were significantly and positively correlated with CRP and TC/HDL-C,and positively correlated with HDL-C.Conclusion The levels of sOX40L in AMI and UA are higher than those of the SA and the NCHD.The levels of sOX40L is positively correlated with inflammatory marker（CRP） and blood lipid（TC/HDL-C）.The sOX40L may probably be used as an early predictive marker for the diagnosis of ACS.

关 键 词：OX40配体/血液 冠状动脉疾病/代谢/诊断 急性病 综合征 C反应蛋白质/代谢 脂类/血液 

分 类 号：R541.4[医药卫生—心血管疾病]