脑震荡患者血清S100B蛋白的变化与认知功能障碍的相关性  

Correlation between changes of serum S100B protein level and cognition disorders in patients with brain concussion

作　　者：林煜[1] 黄传平[1] 刘剑[1] 曹云飞[2] 谢培增[1] 汪先兵[1] 

机构地区：[1]解放军第四二一医院神经外科,广州510318 [2]解放军第四二一医院麻醉科,广州510318

出　　处：《中华神经医学杂志》2010年第8期844-846,共3页Chinese Journal of Neuromedicine

摘　　要：目的 分析脑震荡患者血清S100B含量变化与认知功能损害的相关性,探讨血清S100B水平在脑震荡认知障碍预后判断中的意义. 方法 采用酶联免疫法分别测定126例脑震荡患者急诊入院后6h、12h和第3天的血清S100B浓度,并和同期轻型单纯脑外伤患者比较.脑震荡患者常规治疗后,于入院后第1天、第14天及3个月后进行简易智能精神状态检查量表（MMSE）评估,将S100B浓度与MMSE评分进行相关性分析. 结果入院6 h、12 h后脑震荡组患者血清S100B浓度均明显高于对照组,差异有统计学意义（P＜0.05）.入院6 h血清S100B浓度与各时段MMSE评分均具有相关性（P均＜0.05）;入院12 h、第3天血清S100B浓度与各时段MMSE评分均无相关性（P均＞0.05）. 结论 脑震荡患者早期（6 h）血清S100B含量异常升高,并与认知功能损害有明显相关性,可作为认知功能损害预后判断的重要指标.Objective To investigate the correlation between the changes of serum S100B protein level in acute phase and the scores of mini-mental state examination （MMSE） in patients with brain concussion, and evaluate the role of serum S100B protein level in the prognosis of cognition disorders after brain concussion. Methods The serum S100B protein level was determined by an enzyme linked immunosorbent assay （ELISA） in 126 cases of brain concussion 6 and 12 h, and 3 d after admission, and these data were compared with those in 96 cases of moderate head trauma without transitory loss of consciousness （admitted to our hospital at the same period, control group）. MMSE was performed 1 and 14 d and 3 months after injury, and the correlation between the changes of serum S100B level in acute phase and MMSE scores was observed. Results As compared with that in control group,the serum S100B protein level in patients with brain concussion was significant higher at 6 and 12 h after admission（P＜0.05）. The serum S100B protein level at 6 h, but not at 12 h and 3 d after admission, was closely associated with the MMSE scores 1 and 14 d and 3 months after injury. Conclusion Early elevation of S100B within 6 h of admission in patients with brain concussion, obviously correlating with cognitive impairment, may serve as an important prognostic marker in predicting clinical outcome of cognition disorders after brain injury.

关 键 词：脑震荡 S100B 认知障碍 简易智能精神状态检查量表 

分 类 号：R651.15[医药卫生—外科学]