无花果多糖对环磷酰胺致免疫抑制小鼠免疫功能的影响  

Effects of Ficus Carica Polysaccharide on the Immune Function of Immunosuppressive Mice Induced by Cyclophosphamide

作　　者：王力男[1] 王勤[2] 苗明三[1] 

机构地区：[1]河南中医学院,河南郑州450008 [2]河南省中医院,河南郑州450002

出　　处：《中医学报》2010年第4期676-678,共3页Acta Chinese Medicine

基　　金：国家"十一五"支撑计划(编号:2008BAI53B09)

摘　　要：目的:探讨无花果多糖对免疫抑制小鼠机体免疫功能的影响。方法:以环磷酰胺(Cyclophosphamide,CY)致免疫抑制小鼠为研究对象,观察无花果多糖对免疫抑制小鼠腹腔巨噬细胞吞噬功能、溶血素及溶血空斑形成和外周血淋巴细胞转化的影响。结果:腹腔注射CY可成功建立小鼠免疫抑制模型,大、小剂量无花果多糖组可显著提高免疫抑制小鼠腹腔巨噬细胞吞噬百分率及吞噬指数,可显著促进免疫抑制小鼠溶血素形成、明显促进溶血空斑形成,可显著提高免疫抑制小鼠外周血淋巴细胞转化百分率。结论:无花果多糖对CY所致小鼠免疫抑制有对抗作用。Objective：To explore the effects of Ficus carica polysaccharide on immune function of immunosuppressive mice.Methods：With the immune function of immunosuppres-ive mice induced by CY as the research object,Observe that Ficus carica polysaccharide has the roles in macrophage phagocytosis,hemolysin,Hemolytic plaque formation and peripheral blood lymphocyte transformation of immunosuppressive mice.Results：The model is established by intraperitoneal injection of CY.Both of Ficus carica polysaccharide can extraordinarily improve phagocytosis percentage,phagocytic index hemolysin formation and lymphocyte transformation rate of immunosuppressive mice,and evidently promote the formation of hemolytic plaque.Conclusion：Ficus carica polysaccharide has good effect on immunosuppressive mice induced by CY.

关 键 词：无花果多糖 免疫抑制 免疫功能 小鼠 

分 类 号：R285.5[医药卫生—中药学]