替米沙坦对尿白蛋白排泄率正常的糖尿病患者肾小球滤过率的影响  

Effect of telmisartan on glomerular filtration rate of diabetic patients with normal urinary albumin excretion rate

作　　者：苏宏业[1] 潘海林[1] 黎英荣[1] 肖常青[1] 夏宁[1] 黄媛[1] 何玉玲[1] 黄炫赓[1] 

机构地区：[1]广西医科大学第一附属医院代谢糖尿病中心,南宁530021

出　　处：《中国糖尿病杂志》2010年第7期498-499,共2页Chinese Journal of Diabetes

摘　　要：目的研究替米沙坦对尿白蛋白排泄率(UAER)正常的DM患者肾小球滤过率(GFR)的影响。方法 113例UAER正常的DM患者,口服替米沙坦40mg/d,9～14周,分析治疗前后GFR的变化。结果治疗前DM组的GFR高于对照组(P<0.01);治疗后DM组GFR较治疗前降低(P<0.01);治疗后GFR下降者治疗前的GFR高于非下降者。结论替米沙坦能有效改善UAER正常的DM患者的高GFR状态,对DM患者的肾脏有保护作用。Objective To study the effect of telmisartan on glomerular filtration rate （GFR） of diabetic patients （DM） with normal urinary albumin excretion rate （UAER）. Methods We studied 113 diabetic patients with normal UAER. A dose of 40 mg of telmisartan was given to the patients for 9 to 14 weeks. GFR of these patients was analyzed before and after treatment. Results GFR in the study group was higher than in the control（101. 53 ± 26. 50 vs 85.66 ± 13.09,P〈0.01 ）. GFR of the study group was lower after treatments （91.59 ± 16.64 vs 101.53 ± 26.50, P 〈 0.01 ）. The patients whose GFR was decreased after treatment showed a higher GFR in pretreatment than those with no GFR decrease. Conclusions Telmisartan can improve the high GFR state of diabetic patients with normal UAER, which can provide a protection for the kidney function of diabetic patients.

关 键 词：糖尿病 替米沙坦 肾小球滤过率 尿白蛋白排泄率 

分 类 号：R587.1[医药卫生—内分泌]