汉族2型糖尿病人群中新型足贴欧米诺与振动感觉阈值检查相关性研究  

Correlation study between the new indicator test (Neuropad) and vibration perception thresholds test in Chinese Han patients diagnosed as type 2 diabetes

作　　者：鹿斌 杨志红 王妹 龚伟 杨震 闻杰 杨叶虹 朱禧星 胡仁明 

机构地区：[1]复旦大学附属华山医院内分泌科复旦大学上海医学院内科学系复旦大学内分泌糖尿病研究所,上海200040

出　　处：《中国糖尿病杂志》2010年第7期512-514,共3页Chinese Journal of Diabetes

基　　金：上海市科学技术委员会重大项目(04dz19504);国家自然科学基金重点项目(30230380);上海市卫生局青年基金(2006Y6);复旦大学青年科学基金(08FQ37);复旦大学附属华山医院青年基金(Y186)

摘　　要：目的探讨汉族2型糖尿病(T2DM)人群中新型足贴欧米诺(Neuropad)与振动感觉阈值(VPT)检查的相关情况。方法对482例T2DM患者进行欧米诺和VPT检查,采用Spearman相关分析欧米诺与VPT的相关性。结果 (1)高风险VPT组年龄、DM病程、SBP、Cr均高于非高风险VPT组,HDL-C低于非高风险VPT组;(2)高风险VPT组的独立危险因子为年龄和FPG;(3)双侧足部欧米诺检查显示双侧开始变色时间及完全变色时间之间均显著相关(P均<0.01);(4)VPT与左侧开始变色时间、左侧完全变色时间、右侧开始变色时间及右侧完全变色时间均显著相关。结论新型足贴欧米诺可能作为筛查糖尿病外周神经病变的有效工具。Objective To investigate the correlation between the commercially available Neuropad test and vibration perception thresholds （VPT） test in the Chinese Han patients diagnosed as type 2 diabetes. Methods Both Neuropad test and VPT test were completed in 482 Chinese patients diagnosed as type 2 diabetes aged over 30 years. Body mass measurements, resting blood pressure, fasting blood measures were also investigated. The relationship between Neuropad test and VPT test was evaluated. Results （1） Age, duration of diabetes, systolic blood pressure and serum creatinine were significantly higher in high-risk VPT subgroup than in non-high risk VPT subgroup. HDL C was lower in high-risk VPT subgroup than in non-high-risk VPT subgroup. （2） High-risk VPT was significantly associated with older age（β=0.058, OR=1. 060, CI=1. 036 1. 085,P〈0. 001） and fasting plasma glucose（β=0. 080,OR =1.083, CI=1.002-1.171, P=0.045） by logistic regression analysis. （3） All Neuropad tests in left foot were significantly correlated with those in right foot （P〈0.01）. （4） VPT test was significantly correlated with all Neuropad tests, including time to initial color change of the test in left foot （r=0. 193; P〈0.01）, time to complete color change of the test in left foot （r=0.103; P=0.039）, time to initial color change of the test in right foot （r=0. 207; P〈0.01） and time to complete color change of the test in right foot （r = 0. 157; P〈 0. 01）. Conclusions The Neuropad test might be a simple indicator for screening patients with diabetic neuropathy.

关 键 词：糖尿病 2型 欧米诺 振动感觉阈值检查 

分 类 号：R587.1[医药卫生—内分泌]