辽宁省2004年-2009年流脑病例监测分析  

Surveillant analysis of meningococcal meningitis in Liaoning during 2004-2009

作　　者：付荣华[1] 王萍[2] 王燕[1] 顾松义[1] 孟军[3] 万强[3] 王悦伟[4] 肖太光[5] 安淑一[1] 孙静[1] 

机构地区：[1]辽宁省疾病预防控制中心,沈阳110005 [2]沈阳市疾病预防控制中心,沈阳110031 [3]辽宁省大连市疾病预防控制中心,辽宁大连116021 [4]辽宁省抚顺市疾病预防控制中心,辽宁抚顺113006 [5]辽宁省葫芦岛市疾病预防控制中心,辽宁葫芦岛125000

出　　处：《中国卫生检验杂志》2010年第7期1728-1729,共2页Chinese Journal of Health Laboratory Technology

基　　金：辽宁省医学高峰建设工程项目

摘　　要：目的:分析辽宁省流行性脑脊髓膜炎(流脑)菌群分布和流行特征。方法:收集流脑病例,对流脑病例的脑脊液和血液进行增菌后分离培养、鉴定,密切接触者咽拭子标本,按照国标(GB16884-1997)方法进行培养、鉴定;双份血清检测采用ELISA方法。结果:从病例中分离到8株流脑菌,A群6株,占75%,B群2株,占25%;11例抗体呈4倍增高,A群5例,占45.5%,C群6例,占54.5%。从密切接触者中分离到流脑菌40株:A群29株,占72.5%;B群1株,占2.5%;C群4株,占10.0%;W135群1株,占2.5%;未定型5株,占12.5%。而流脑的发病数大幅下降后,以1～7岁组下降明显,大年龄组发病比例增加。结论:我省流脑仍以A群为优势菌群,但2004年以后出现C群病例,且流脑发病年龄后移,应密切注意C群流脑扩散趋势,加强流脑病原学监测,采取相应措施,控制流脑病例发生。Objective：To analyze the flora distribution of Neisseria meningitis（Nm） and epidemiological characteristic in Liaoning province.Methods：Collect meningococcal meningitis cases;Bacteria from cerebrospinal fluid and blood of meningococcal meningitis cases which were tested was isolated culture and identified,throat swab samples of close contacts in accordance with the national standard（GB16884-1997） approach to culture,identification;double serum were detected by ELISA.Results：8 strains were isolated from meningococcal meningitis cases,the proportion of Nm serogroup A and B were 75%（6 strains） and 25%（2 strains）.11 cases of antibody showed four double high,including serogroup A for 45.5%（5 cases）,serogroup C for 54.5%（6 cases）.The strains from close contacts were 40,including the serogroup A,B,C,W135 and undetermined type were 29,1,4,1 and 5 respectively,the proportion of Nm serogroup were 72.5%,2.5%,10.0%,2.5% and 12.5% following.The incidence of meningococcal meningitis after a sharp drop to a 1-7 year-old group significantly decreased,the incidence of older groups increased proportionately.Conclusion：The dominant bacterial strain of Nm was still serogroup A in Liaoning province,After 2004,the serogroup C cases occurred and the incidence age increased,to pay close attention to serogroup C tendency to spread,strengthen pathogeny surveillance,take measures to control meningococcal meningitis cases occurred.

关 键 词：流行性脑脊髓膜炎 菌群分布 流行特征 监测 

分 类 号：R515.2[医药卫生—内科学]