卵胞浆内单精子显微注射子代临床随访研究  

A follow-up study on children conceived through intracytoplasmic sperm injection

作　　者：余慕雪[1] 徐艳文[2] 周灿权[2] 庄思齐[1] 王子莲[3] 陈玮琪[1] 李晓瑜[1] 邓明芬[2] 

机构地区：[1]中山大学附属第一医院儿科,广州510080 [2]中山大学附属第一医院生殖医学中心,广州510080 [3]中山大学附属第一医院产科,广州510080

出　　处：《中华流行病学杂志》2010年第8期929-932,共4页Chinese Journal of Epidemiology

基　　金：国家重点基础研究发展计划（973计划）（2007CB948103）;高等学校博士学科点专项科研基金（20050558097）

摘　　要：目的 了解卵胞浆内单精子显微注射（ICSI）子代围产期并发症、出生缺陷和生长发育等状况.方法 对中山大学附属第一医院生殖医学中心经ICSI技术治疗妊娠成功的575例ICSI子代进行临床随访分析,内容包括孕母妊娠期并发症、子代新生儿期并发症、围产期出生缺陷和以后发现的出生缺陷以及体重、身长/高增长状况等.结果 多胎妊娠ICSI子代早产、低出生体重儿发生率较单胎妊娠子代高;孕母妊娠高血压综合征和ICSI子代新生儿窒息、呼吸窘迫综合征、感染性疾病的发生率在多胎妊娠子代中发生率也较高（P＜0.05）.11例死亡的ICSI子代中,10例在新生儿期死亡,均为早产儿;1例单胎足月儿2岁死于肝母细胞瘤.多胎妊娠ICSI子代围产期出生缺陷的发生率较一般人群调查的发生率高（P＜0.05）.大部分ICSI子代1～3岁的体重、身长/身高能达到同龄儿童标准范围.结论 ICSI子代围产期并发症较高发生率与多胎妊娠密切相关.Objective To investigate the perinatal complications, birth defects and growth of children conceived through intracytoplasmic sperm injection （ICSI）. Methods A total of 575 children conceived by ICSI in our reproductive medical center, were studied. The follow-up study would include items as pregnant complications, neonatal complications, birth defects in perinatal period, subsequently detected birth defects, body weight and body length/height growth. Results Prematurity and low birth weight of ICSI children were higher in the multiple births than in the singleton births. The rates of materal gestational hypertension, neonatal asphyxia, respiratory distress syndrome, infection diseases were higher in the multiple pregnancies than in the singleton pregnancies（P〈0.05）. Eleven ICSI children had died. Ten of them died in the neonatal period and they were preterm infants. One fullterm singleton ICSI child died of hepatoblastoma at the age of 2. The rate of birth defects in perinatal period was higher in ICSI children of multiple pregnancies than in the general population （P〈0.05）. The body weight and body length/height of most ICSI children had obtained the standard range between 1 to 3 year-olds. Conclusion The higher rates of perinatal complications in ICSI children were closely related to multiple pregnancies.

关 键 词：卵胞浆内单精子显微注射 围产期 多胎妊娠 出生缺陷 

分 类 号：R714.8[医药卫生—妇产科学]