2型糖尿病患者治疗前后内脂素与内皮素及胰岛素抵抗的关系  

The relationship among plasma visfatin,endothelin, and insulin resistance in type 2 diabetic patients before and after treatment

作　　者：高谷[1] 李倩[1] 袁璐[1] 丁波[1] 李惠琴[1] 马建华[1] 齐绍康[1] 

机构地区：[1]南京医科大学附属南京第一医院内分泌科,210006

出　　处：《中华内分泌代谢杂志》2010年第7期588-590,共3页Chinese Journal of Endocrinology and Metabolism

基　　金：南京市医学科技发展项目（ZKM06036）

摘　　要：探讨2型糖尿病发病机制中内脂素与内皮素及胰岛素抵抗的关系.比较治疗前后内皮素、内脂素等指标.治疗后内脂素水平降低,内皮素与空腹胰岛素、稳态模型评估的胰岛素抵抗指数（HOMA-IR）、稳态模型评估的胰岛β细胞功能（HOMA-β）、内脂素正相关,内脂素与内皮素、HbA1c、空腹胰岛素、HOMA-IR正相关,HOMA-IR是血浆内脂素的独立相关因素.内脂素与内皮素、胰岛索抵抗有关,可能与2型糖尿病及胰岛素抵抗的发病机制密切相关.The relationship between visfatin.endothelin, and insulin resistance in the pathogenesis of type 2 diabetes mellitus was explored. Endothelin, visfatin, and other markers were compared. Plasma visfatin was reduced after therapy. Endothelin was positively correlated with fasting insulin, HOMA-IR, HOMA-p, and visfatin. Visfatin was positively correlated with endothelin, HbA1C , fasting insulin, and HOMA-IR. HOMA-IR was an independent related factor in influencing visfatin. The visfatin is related to endothelin and insulin resistance, which may contribute to the pathogenesis of insulin resistance and type 2 diabetes mellitus.

关 键 词：糖尿病 2型 内脂素 内皮素 胰岛素抵抗 甘精胰岛素 

分 类 号：R587.1[医药卫生—内分泌]