巴尼地平自微乳化液大鼠在体小肠吸收动力学研究  

Studies on Absorption Kinetics of Barnidipine Self-microemulsion on the Small Intestine of Rats

作　　者：何艳[1] 辛华雯[1] 余爱荣[1] 李高[2] 

机构地区：[1]广州军区武汉总医院临床药理科,武汉430070 [2]华中科技大学同济医学院药剂教研室

出　　处：《中国药师》2010年第8期1084-1086,共3页China Pharmacist

摘　　要：目的:通过大鼠在体小肠吸收实验方法,研究巴尼地平自微乳大鼠小肠吸收动力学。方法:以微乳肠循环液中的巴尼地平含量为指标,计算吸收速率常数(Ka)以及3 h的吸收百分数(PA)。结果:巴尼地平自微乳肠循环液灌流3 h后,胆管结扎的大鼠小肠药物吸收百分率为80.73%,胆管未结扎的大鼠小肠药物吸收百分率为81.74%。结论:巴尼地平自微乳化液透膜性好,吸收较快。胆管结扎与否小肠吸收率无显著影响(P>0.05)。Objective： To study the absorption kinetics of barnidipine self-microemulsion on the small intestine of rats. Method： The absorption rate （Ka） and the percentage of 3h absorption（PA） in the intestinal fluid were calculated by using the content of barni- dipine as index. Result： The absorption rates were 80.73% and 81.74% after bamidipine perfusion for 3 h in with and without the bile duct ligated, respectively. Conclusion： Barnidipine self-microemulsion has good membrane permeability, and absorps rapidly. There is no significant impact on the absorption rate （ P 〉 0. 05 ） whether the bile duct is ligated or not.

关 键 词：巴尼地平 自微乳化 小肠吸收 胆管结扎 

分 类 号：R945[医药卫生—微生物与生化药学]