芒果止咳合剂的处方优选  

Optimization of Prescription of Mango Anti-Cough Mixture

作　　者：谢黎崖[1] 张真[2] 黄鑫[2] 

机构地区：[1]厦门大学附属第一医院,福建厦门361003 [2]厦门大学医学院药学系

出　　处：《中国药师》2010年第8期1138-1139,共2页China Pharmacist

摘　　要：目的:优选芒果止咳合剂的处方配比。方法:制备不同配比的芒果止咳合剂分为A、B、C组,以生理盐水为阴性对照组,采用小鼠镇咳试验法及小鼠耳廓肿胀法,以咳嗽潜伏期、每分钟咳嗽次数和耳廓肿胀度为考察指标考察各组镇咳抗炎的效果。结果:与阴性组相比,A、B、C组对小鼠咳嗽潜伏期有显著延长作用(P<0.05或0.01),对小鼠每分钟咳嗽次数有显著减少作用(P<0.01),对小鼠耳廓肿胀有显著的抑制作用(P<0.05或0.01)。结论:3种配比芒果止咳合剂均有镇咳和抗炎作用,其中C组的镇咳作用最强,B组和C组的抗炎作用最强,故C组配比可作为芒果止咳合剂的最优配比。Objective： To optimize the best proportion of the mango anti-cough mixture （ MCM ）. Method： By preparation of the different prescription of MCM, A, B and C group were signed. Normal saline was setted as a negative control group and the cough-relie- ving test of mice and mice ear edema modes was used. The latency of cough, the cough times per I minute and mice ear edema were set- ted as indexes. Result： Compared with negative control group, three proportions of MCM were significantly prolonged the latency of cough （P 〈 0. 05 or 0. 01 ） , reduced the cough times per 1 minute （ P 〈 0. 01 ） and had inhibitory effect on mice ear edema （P 〈0. 05 or 0. 01 ）. Conclusion： All the three proportions of MCM have antititussive and anti-inflammatory effects. The antititussive action of group C was the strongest in the three groups. The anti-inflammatory effect of group B and C were more stronger. So the optimal proportion of MCM was group C.

关 键 词：芒果止咳合剂 镇咳 抗炎 

分 类 号：R285.5[医药卫生—中药学]