医院感染铜绿假单胞菌的耐药性变迁及临床对策  

Drug Resistance of Pseudomonas aeruginosa:Four Year Dynamics and Clinical Antimicrobial Strategy

作　　者：陈洁[1] 潘景业[1] 王晓蓉[1] 马继红[1] 周小洁[1] 

机构地区：[1]温州医学院附属第一医院ICU,浙江温州325000

出　　处：《中华医院感染学杂志》2010年第15期2311-2313,共3页Chinese Journal of Nosocomiology

摘　　要：目的分析临床分离的铜绿假单胞菌的耐药性及其变迁,为临床合理用药提供依据。方法对医院2005年1月-2008年12月住院患者各种标本中分离到的铜绿假单胞菌982株,采用20种抗菌药物进行药敏试验,并比较4年的变迁。结果分离到的铜绿假单胞菌对氨苄西林、阿莫西林/克拉维酸、氨苄西林/舒巴坦、头孢替坦、头孢唑林、呋喃妥因、磺胺甲噁唑/甲氧苄啶的耐药率均>90.00%;对碳青酶烯类美罗培南产生了51.51%的耐药率;对庆大霉素、头孢他啶、头孢匹美、头孢哌酮/舒巴坦、环丙沙星的敏感率均>60.00%;而最敏感的是阿米卡星、妥布霉素。结论医院感染铜绿假单胞菌非常严重,对多种抗菌药物具有高度耐药性,应加强监测,根据药敏试验选用合理抗菌药物。OBJECTIVE To analyze the change in antibiotic resistance of Pseudomonas aeruginosa（PAE） in our hospital during the past four years for reference of clinical antimicrobial strategy.METHODS Data from Jan 2005 to Dec 2008 were collected of the 982 P.aeruginosa strains isolated from clinical specimens.Drug sensitivity to 20 antimicrobial agents were tested.RESULTS The drug resistance rates were mostly higher than 90.00%,including to ampicillin,amoxicillin/clavulanic acid,ampicillin/sulbactam,cefotetan,cephazolin,furadantin,and trimethoprim/sulfamethoxazole,but to meropenem was 51.51%.Some drug sensitive rates were higher than 60.00%,including gentamicin,ceftazidime,cefepime,cefoperazone/sulbactam,and ciprofloxacin.But the resistance rate to amikacin and tobramycin was the lowest.CONCLUSIONS The resistance of PAE to the most of the antibiotics is increasing in clinical specimens.Antimicrobial treatment should be guided by drug sensitivity test.

关 键 词：铜绿假单胞菌 医院感染 耐药性 

分 类 号：R378.991[医药卫生—病原生物学]